Biosensor Team, Electronics and Telecommunications Research Institute, 218 Gajeong-no, Yuseong-gu, Daejeon, 305-700, Republic of Korea.
Lab Chip. 2012 Sep 21;12(18):3272-6. doi: 10.1039/c2lc40529f. Epub 2012 Jul 25.
We present a novel blood filter unit that is designed to separate blood plasma from whole blood by simple magnetic actuation. A non-diluted blood sample is dropped into the filter unit and magnetic attraction is applied to squeeze out only blood plasma while blood particles are filtered by membranes stacked in the filter unit. The new filter device yields good filtering performance with nearly perfect filtering efficiency (∼99.999%), high plasma recovery (∼30%), low blood consumption (<50 μl), and fast operation (∼1 min). Because it is simple to operate and is attachable to any kind of pre-made biochip, it has commercial potential in various lab-on-a-chip applications for blood tests.
我们提出了一种新颖的血液过滤单元，该单元通过简单的磁驱动设计用于分离全血中的血浆。将未经稀释的血样滴入过滤单元中，并施加磁场吸引力，仅挤出血浆，而血液颗粒则被过滤单元中堆叠的膜过滤。新型过滤装置具有良好的过滤性能，过滤效率几乎达到 100%（约 99.999%），血浆回收率高（约 30%），血液消耗少（<50 μl），操作速度快（约 1 分钟）。由于操作简单，并且可以连接到任何类型的预制生物芯片上，因此它在各种用于血液检测的芯片实验室应用中具有商业潜力。
