用于操纵、成像和筛选秀丽隐杆线虫的微流控方法。
Microfluidic Approaches for Manipulating, Imaging, and Screening C. elegans.
作者信息
Gupta Bhagwati P, Rezai Pouya
机构信息
Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada.
Department of Mechanical Engineering, York University, Toronto, ON M3J 1P3, Canada.
出版信息
Micromachines (Basel). 2016 Jul 19;7(7):123. doi: 10.3390/mi7070123.
The nematode (worm) is a small invertebrate animal widely used in studies related to fundamental biological processes, disease modelling, and drug discovery. Due to their small size and transparent body, these worms are highly suitable for experimental manipulations. In recent years several microfluidic devices and platforms have been developed to accelerate worm handling, phenotypic studies and screens. Here we review major tools and briefly discuss their usage in research.
线虫是一种小型无脊椎动物，广泛应用于与基础生物学过程、疾病建模和药物发现相关的研究中。由于其体型小且身体透明，这些线虫非常适合进行实验操作。近年来，已经开发了几种微流控设备和平台，以加速线虫处理、表型研究和筛选。在此，我们综述主要工具并简要讨论它们在研究中的应用。
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