Birkholz Mario, Glogener Paul, Glös Franziska, Basmer Thomas, Theuer Lorenz
IHP, Im Technologiepark 25, 15236 Frankfurt (Oder), Germany.
Department of Biotechnology, Technical University Berlin, ACK24, Ackerstr. 76, 13355 Berlin, Germany.
Micromachines (Basel). 2016 Oct 9;7(10):183. doi: 10.3390/mi7100183.
An integration concept for an implantable biosensor for the continuous monitoring of blood sugar levels is presented. The system architecture is based on technical modules used in cardiovascular implants in order to minimize legal certification efforts for its perspective usage in medical applications. The sensor chip operates via the principle of affinity viscometry, which is realized by a fully embedded biomedical microelectromechanical systems (BioMEMS) prepared in 0.25-µm complementary metal⁻oxide⁻semiconductor (CMOS)/BiCMOS technology. Communication with a base station is established in the 402⁻405 MHz band used for medical implant communication services (MICS). The implant shall operate within the interstitial tissue, and the hermetical sealing of the electronic system against interaction with the body fluid is established using titanium housing. Only the sensor chip and the antenna are encapsulated in an epoxy header closely connected to the metallic housing. The study demonstrates that biosensor implants for the sensing of low-molecular-weight metabolites in the interstitial may successfully rely on components already established in cardiovascular implantology.
提出了一种用于连续监测血糖水平的植入式生物传感器的集成概念。系统架构基于心血管植入物中使用的技术模块，以便在其用于医疗应用的预期使用中尽量减少法律认证工作。传感器芯片通过亲和粘度测定原理运行，这是由采用0.25微米互补金属氧化物半导体（CMOS）/双极互补金属氧化物半导体（BiCMOS）技术制备的完全嵌入式生物医学微机电系统（BioMEMS）实现的。与基站的通信在用于医疗植入通信服务（MICS）的402 - 405 MHz频段中建立。植入物应在间质组织内运行，并且使用钛外壳实现电子系统与体液相互作用的气密密封。只有传感器芯片和天线封装在紧密连接到金属外壳的环氧管座中。该研究表明，用于感测间质中低分子量代谢物的生物传感器植入物可以成功地依赖于心血管植入学中已经确立的组件。
