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一种新型可配置无线传感器系统，用于生物医学应用，具有 ISO 18000-3 接口，采用 0.35 µm CMOS 工艺。

A New Configurable Wireless Sensor System for Biomedical Applications with ISO 18000-3 Interface in 0.35 µm CMOS.

机构信息

Fraunhofer IMS, 47057 Duisburg, Germany.

Department of Electronic Components and Circuits, University of Duisburg-Essen, 47057 Duisburg, Germany.

出版信息

Sensors (Basel). 2019 Sep 23;19(19):4110. doi: 10.3390/s19194110.

DOI:10.3390/s19194110
PMID:31547579
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6806625/
Abstract

This article presents a new configurable wireless sensor system. The system is used to perform amperometric measurements and send the measurement data to a handheld reader using a wireless transponder interface. The two-chip sensor system was implemented in a 0.35 μm CMOS technology. The system consists of an integrated nano-potentiostat that performs the actual measurements and an ISO 18000-3 compliant frontend that enables wireless telemetric data transmission and powering of the entire sensor system. The system was manufactured in combination with a chronoamperometric glucose sensor which allows the measurement of the glucose content in tear fluid and thus a non-invasive determination of the blood sugar level. For a range of sensor currents from 0.1 μA to 10 μA, the potentiostat achieved an accuracy of better than 5 % with a total power dissipation of less than 600 μW. With the realized antenna geometry a wireless communication distance of more than 7 cm has been achieved.

摘要

本文提出了一种新的可配置无线传感器系统。该系统用于执行电流测量，并使用无线应答器接口将测量数据发送到手持读取器。该两芯片传感器系统采用 0.35μm CMOS 技术实现。该系统由执行实际测量的集成纳米安培计和符合 ISO 18000-3 的前端组成，该前端允许进行无线遥测数据传输和整个传感器系统的供电。该系统与chronoamperometric 葡萄糖传感器结合制造，该传感器允许测量泪液中的葡萄糖含量，从而可以无创地确定血糖水平。对于 0.1μA 至 10μA 的一系列传感器电流，该安培计的精度优于 5%，总功耗小于 600μW。通过实现的天线几何形状，实现了超过 7cm 的无线通信距离。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fa0/6806625/eb30d57dc5f7/sensors-19-04110-g020.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fa0/6806625/639fe12aedba/sensors-19-04110-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fa0/6806625/050ce30bf29b/sensors-19-04110-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fa0/6806625/8db129e1b590/sensors-19-04110-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fa0/6806625/b5df28d593f3/sensors-19-04110-g017.jpg
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本文引用的文献

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Clinical Evidence for Use of a Noninvasive Biosensor for Tear Glucose as an Alternative to Painful Finger-Prick for Diabetes Management Utilizing a Biopolymer Coating.临床证据表明，使用非侵入性生物传感器测量泪液葡萄糖可替代痛苦的手指穿刺，用于利用生物聚合物涂层进行糖尿病管理。
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An Implantable RFID Sensor Tag toward Continuous Glucose Monitoring.一种用于连续血糖监测的可植入式射频识别传感器标签。
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