Gallo V, Suergiu R, Levi G
Eur J Pharmacol. 1987 Jun 19;138(2):293-7. doi: 10.1016/0014-2999(87)90448-1.
Micromolar concentrations of kainic acid and quisqualic acid released [3H]D-aspartate preaccumulated by cerebellar granule cells in culture. The effect of kainate was selectively antagonized by kynurenic acid and, less effectively, by PDA. Kainate and quisqualate also increased [3H]GABA release from a subpopulation of cultured cerebellar astrocytes. Kynurenic acid selectively blocked the effect of kainic acid. NMDA and no D-aspartate or GABA releasing effect. These results suggest the existence of two different excitatory amino acid sites active on neurotransmitter amino acid release in both cerebellar granule cells and astrocytes.
微摩尔浓度的红藻氨酸和quisqualic酸可释放培养的小脑颗粒细胞预先积累的[3H]D-天冬氨酸。犬尿烯酸可选择性拮抗红藻氨酸的作用，而3,4-二羟基苯乙酸的拮抗作用较弱。红藻氨酸和quisqualate还可增加培养的小脑星形胶质细胞亚群中[3H]GABA的释放。犬尿烯酸可选择性阻断红藻氨酸的作用。NMDA无D-天冬氨酸或GABA释放作用。这些结果表明，在小脑颗粒细胞和星形胶质细胞中，存在两种不同的兴奋性氨基酸位点，它们对神经递质氨基酸的释放具有活性。
