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Glutamate and GABA receptors in vertebrate glial cells.

作者信息

von Blankenfeld G, Kettenmann H

机构信息

Department of Neurobiology, University of Heidelberg, FRG.

出版信息

Mol Neurobiol. 1991 Spring;5(1):31-43. doi: 10.1007/BF02935611.

DOI:10.1007/BF02935611
PMID:1687351
Abstract

Glial cells of the central nervous system express receptors for the main inhibitory and excitatory neurotransmitters, GABA and glutamate. The glial GABA and glutamate receptors share many properties with the neuronal GABAA and kainate/quisqualate receptors, but are molecularly and, in some aspects, pharmacologically distinct from their neuronal counterparts. The functional role of these receptors is as yet speculative: They have been proposed to control proliferation of astrocytes, serve to balance ion changes at GABAergic synapses, or they could enable the glial cell to detect neuronal synaptic activity.

摘要

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Expression and Developmental Regulation of a GABAA Receptor in Cultured Murine Cells of the Oligodendrocyte Lineage.
Eur J Neurosci. 1991;3(4):310-316. doi: 10.1111/j.1460-9568.1991.tb00817.x.
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gamma-Aminobutyric acid directly depolarizes cultured oligodendrocytes.γ-氨基丁酸可直接使培养的少突胶质细胞去极化。
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靶星形胶质细胞与皮质神经元轴突之间的半突触形成
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Muscimol Directly Activates the TREK-2 Channel Expressed in GABAergic Neurons through Its N-Terminus.蘑菇氨酸通过其 N 端直接激活 GABA 能神经元表达的 TREK-2 通道。
Int J Mol Sci. 2021 Aug 27;22(17):9320. doi: 10.3390/ijms22179320.
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SNAP25 Inhibits Glioma Progression by Regulating Synapse Plasticity GLS-Mediated Glutaminolysis.SNAP25通过调节突触可塑性和GLS介导的谷氨酰胺分解来抑制胶质瘤进展。
Front Oncol. 2021 Aug 16;11:698835. doi: 10.3389/fonc.2021.698835. eCollection 2021.
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Pathway analysis of glutamate-mediated, calcium-related signaling in glioma progression.谷氨酸介导的、钙相关信号通路在胶质瘤进展中的作用分析。
Biochem Pharmacol. 2020 Jun;176:113814. doi: 10.1016/j.bcp.2020.113814. Epub 2020 Jan 16.
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microRNA Expression Profiling of Propofol-Treated Developing Rat Hippocampal Astrocytes.异丙酚处理的发育中大鼠海马星形胶质细胞的微小RNA表达谱分析
DNA Cell Biol. 2015 Aug;34(8):511-23. doi: 10.1089/dna.2015.2831. Epub 2015 Jun 17.
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New vistas on astroglia in convulsive and non-convulsive epilepsy highlight novel astrocytic targets for treatment.癫痫发作和非癫痫发作中的星形胶质细胞的新观点强调了新的星形胶质细胞治疗靶点。
J Physiol. 2013 Feb 15;591(4):775-85. doi: 10.1113/jphysiol.2012.243378. Epub 2012 Dec 10.
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Pharmacol Rev. 2012 Jul;64(3):780-802. doi: 10.1124/pr.110.003889.
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Uptake of the neurotransmitter candidate glutamate by glia.
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Functional evaluation of glutamate receptor subtypes in cultured cerebellar neurones and astrocytes.培养的小脑神经元和星形胶质细胞中谷氨酸受体亚型的功能评估
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Glutamate opens Na+/K+ channels in cultured astrocytes.谷氨酸可打开培养的星形胶质细胞中的钠钾通道。
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