醉鱼草苷J和K：从醉鱼草果实中分离得到的两种新型神经保护三萜类化合物。

Mimengosides J and K: two new neuroprotective triterpenoids from the fruits of Buddleja lindleyana.

作者信息

Zhang Wei, Li Zheng, Xu Feng-Qing, Ren Ya-Shuo, Xu Shuang-Wang, Wang Tong-Sheng, Liu Jin-Song, Wu De-Ling

机构信息

a School of Pharmacy , Anhui University of Chinese Medicine , Hefei 230012 , China.

b Synergetic Innovation Center of Anhui Authentic Chinese Medicine Quality Improvement , Hefei 230012 , China.

出版信息

J Asian Nat Prod Res. 2019 May;21(5):426-434. doi: 10.1080/10286020.2018.1516211. Epub 2018 Nov 7.

DOI:10.1080/10286020.2018.1516211

PMID:30404553

Abstract

Two new 11-methoxyl substituted triterpenoids, named as mimengosides J (1) and K (2), along with seven known compounds, were isolated from the fruits of Buddleja lindleyana. Their structures were elucidated on the basis of spectroscopic analysis. In addition, the new ones were evaluated for protective effects against damage of SH-SY5Y cells induced by 1-methyl-4-phenylpyridinium ion (MPP) and the results indicated that those may be one of the candidate compositions of Buddleja lindleyana for the treatment of neurodegenerative disease.

摘要

从醉鱼草果实中分离得到两个新的11-甲氧基取代三萜类化合物，命名为醉鱼草苷J（1）和K（2），以及七个已知化合物。通过光谱分析确定了它们的结构。此外，对新化合物进行了抗1-甲基-4-苯基吡啶离子（MPP）诱导的SH-SY5Y细胞损伤的保护作用评估，结果表明这些化合物可能是醉鱼草治疗神经退行性疾病的候选成分之一。