State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
J Nat Prod. 2014 Feb 28;77(2):411-5. doi: 10.1021/np400937f. Epub 2014 Jan 16.
Six novel iridal-type triterpenoids with a previously unreported 3,6-dihydro-2H-pyran moiety, named spirioiridotectals A-F (1-6), were isolated from the ethanol extract of the rhizomes of Iris tectorum. Their structures were elucidated on the basis of extensive spectroscopic analysis. Furthermore, in in vitro bioactivity assays, compounds 1, 2, and 6 exhibited neuroprotective activities against serum-deprivation-induced PC12 cell damage.
从鸢尾的根茎乙醇提取物中分离得到了 6 种新型的虹膜型三萜类化合物，命名为 spirioiridotectals A-F（1-6），它们具有以前未报道的 3,6-二氢-2H-吡喃部分。基于广泛的光谱分析确定了它们的结构。此外，在体外生物活性测定中，化合物 1、2 和 6 表现出对血清剥夺诱导的 PC12 细胞损伤的神经保护活性。
