Liu Limei, Wang Yi, Liu Ju, Liu Wu
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijng Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.
Department of Ophthalmology, Yantai Yuhuangding Hospital, Affiliated Hospital of Medical College, Qingdao University, Yantai, Shandong, China.
BMC Ophthalmol. 2018 Nov 7;18(1):290. doi: 10.1186/s12886-018-0957-1.
To investigate the effect of idiopathic epiretinal membrane (ERM) on the retinal-image quality and psychophysical contrast sensitivity function (CSF).
Forty-four subjects with diagnosis of idiopathic unilateral ERM were enrolled in this cross-sectional observational clinical study. The fellow unaffected eyes were set as the control group. For retinal-image quality assessment, an Optical Quality Analysis System (OQAS) based on double-pass technique was used to evaluate objective scatter index (OSI) and Strehl ratio. For visual performance, the CSF under photopic condition was measured.
For retinal-image quality, the result of double-pass device revealed a significant lower Strehl ratio and larger OSI in the ERM eyes compared to the fellow eyes (all P < 0.05). For visual performance, the CSF at all spatial frequencies under photopic condition were also significantly degraded in the ERM eyes compared to the fellow eyes (all P < 0.05). For the ERM eyes, the reduction of Strehl ratio and CSF was 29.41 and 54.39%, respectively, and the increase of OSI was 164.10% compared to the fellow eyes. Besides, BCVA significantly correlated to the total CSF (ERM eyes, r = - 0.53, P < 0.001; the fellow eyes, r = - 0.467, P = 0.002) and Strehl ratio (ERM eyes, r = - 0.485, P = 0.001; the fellow eyes, r = - 0.311, P = 0.043) in both of the ERM and the fellow eyes.
Eyes affected with ERM showed poorer retinal-image quality and visual performance than the normal eyes. Retinal-image quality measured by OQAS based on double-pass technique could be useful for assessing the retinal-image quality for ERM-affected eyes, in which retinal scattering was significantly increased.
探讨特发性视网膜前膜（ERM）对视网膜图像质量及心理物理学对比敏感度函数（CSF）的影响。
44例诊断为特发性单侧ERM的受试者纳入本横断面观察性临床研究。将对侧未受影响的眼设为对照组。对于视网膜图像质量评估，使用基于双程技术的光学质量分析系统（OQAS）评估客观散射指数（OSI）和斯特列尔比。对于视觉功能，测量明视条件下的CSF。
对于视网膜图像质量，双程设备的结果显示，与对侧眼相比，ERM眼的斯特列尔比显著降低，OSI增大（均P<0.05）。对于视觉功能，与对侧眼相比，ERM眼在明视条件下所有空间频率的CSF也显著下降（均P<0.05）。与对侧眼相比，ERM眼的斯特列尔比降低了29.41%，CSF降低了54.39%，OSI增加了164.10%。此外，在ERM眼和对侧眼中，最佳矫正视力（BCVA）与总CSF（ERM眼，r=-0.53，P<0.001；对侧眼，r=-0.467, P=0.002）和斯特列尔比（ERM眼，r=-0.485，P=0.001；对侧眼，r=-0.,311，P=0.043）均显著相关。
与正常眼相比，患有ERM的眼睛视网膜图像质量和视觉功能较差。基于双程技术的OQAS测量的视网膜图像质量可用于评估受ERM影响的眼睛的视网膜图像质量，其中视网膜散射显著增加。
