一种灵活的有机反射血氧计阵列。
A flexible organic reflectance oximeter array.
机构信息
Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA 94720;
Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA 94720.
出版信息
Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):E11015-E11024. doi: 10.1073/pnas.1813053115. Epub 2018 Nov 7.
Transmission-mode pulse oximetry, the optical method for determining oxygen saturation in blood, is limited to only tissues that can be transilluminated, such as the earlobes and the fingers. The existing sensor configuration provides only single-point measurements, lacking 2D oxygenation mapping capability. Here, we demonstrate a flexible and printed sensor array composed of organic light-emitting diodes and organic photodiodes, which senses reflected light from tissue to determine the oxygen saturation. We use the reflectance oximeter array beyond the conventional sensing locations. The sensor is implemented to measure oxygen saturation on the forehead with 1.1% mean error and to create 2D oxygenation maps of adult forearms under pressure-cuff-induced ischemia. In addition, we present mathematical models to determine oxygenation in the presence and absence of a pulsatile arterial blood signal. The mechanical flexibility, 2D oxygenation mapping capability, and the ability to place the sensor in various locations make the reflectance oximeter array promising for medical sensing applications such as monitoring of real-time chronic medical conditions as well as postsurgery recovery management of tissues, organs, and wounds.
传输模式脉搏血氧仪是一种用于测量血液中氧饱和度的光学方法,它仅限于可以透射的组织,如耳垂和手指。现有的传感器配置仅提供单点测量,缺乏 2D 氧合图能力。在这里,我们展示了一种由有机发光二极管和有机光电二极管组成的柔性和印刷传感器阵列,它通过感应组织反射光来确定氧饱和度。我们使用反射血氧计阵列超越传统的传感位置。该传感器被实现为测量额头上的氧饱和度,平均误差为 1.1%,并在加压袖带诱导缺血下创建成人前臂的 2D 氧合图。此外,我们提出了数学模型来确定存在和不存在脉动动脉血液信号时的氧合情况。反射血氧计阵列具有机械柔韧性、2D 氧合图能力以及在不同位置放置传感器的能力,使其在医疗传感应用中具有广阔的前景,如实时慢性疾病监测以及组织、器官和伤口手术后的恢复管理。