Sano Yuto, Miyazaki Mai, Yaegashi Rina, Okamoto Minoru, Masuko Arisa, Maehara Seiya, Matsuda Kazuya
Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan.
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan.
J Vet Med Sci. 2019 Jan 8;81(1):30-34. doi: 10.1292/jvms.18-0369. Epub 2018 Nov 6.
An 8-year-old castrated Toy poodle presented with swelling and proptosis of the right third eyelid caused by an exophytic mass on the bulbar surface. Histologically, the mass was composed of stratified neoplastic basaloid cells, arranged in nests and interconnecting islands, which were mixed with tubular structures. Immunohistochemically, the basaloid cells were positive for p63 and cytokeratin (CK) 14, and the inner epithelial cells of the tubular structures were positive for CK7, CK8, and CK19. According to these findings, the mass was diagnosed as a basal cell adenocarcinoma. Although basal cell adenocarcinoma is rare in animals, it should be included in the list of differential diagnoses for superficial tumors of bulbar conjunctiva of third eyelid in dogs.
一只8岁去势的玩具贵宾犬因球结膜表面的外生性肿物导致右侧第三眼睑肿胀和脱出。组织学上,肿物由分层的肿瘤性基底样细胞组成,排列成巢状和相互连接的岛状,并与管状结构混合。免疫组织化学检查显示,基底样细胞p63和细胞角蛋白(CK)14呈阳性,管状结构的内层上皮细胞CK7、CK8和CK19呈阳性。根据这些结果,该肿物被诊断为基底细胞腺癌。尽管基底细胞腺癌在动物中罕见,但在犬第三眼睑球结膜浅表肿瘤的鉴别诊断清单中应包括该病。