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补充可通过激活自噬来改善小鼠的糖尿病肾病和肝脂肪变性。

Supplementation of Ameliorates Diabetic Nephropathy and Hepatic Steatosis by Activating Autophagy in Mice.

机构信息

Department of Pharmacology, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 52727, Korea.

Department of Convergence Medical Sciences, Institute of Health Sciences, Gyeongsang National University Graduate School, Jinju 52727, Korea.

出版信息

Nutrients. 2018 Nov 7;10(11):1703. doi: 10.3390/nu10111703.

DOI:10.3390/nu10111703
PMID:30405076
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6266484/
Abstract

Diabetic nephropathy (DN) is a diabetic complication marked by albuminuria and a decline of the glomerular filtration rate. Diabetic kidneys are defective in the autophagy process and mitochondrial function and their enhancement of activity alleviates the pathology. In this paper, we developed a mouse model of DN by a combined treatment of a high-fat diet and streptozotocin after unilateral nephrectomy and supplementation with flower or leaf extracts of (AM) were tested. The preventive effects of the extracts on DN pathology and changes on autophagy and mitochondrial proteins were investigated. DN mice showed a significant increase in fasting blood glucose, plasma creatinine, blood urea nitrogen, and urinary albumin levels. Periodic acid⁻Schiff and Sirius red staining of the diabetic kidney presented a significant change in glomerular and tubular structures that was associated with podocyte loss and fibrotic protein accumulation. These changes were attenuated by AM extract treatment in DN mice. In addition, hepatic injury, proinflammatory cytokines, and lipid accumulation were decreased by AM extracts in DN mice. As a protective mechanism, AM extracts significantly increased the expression of proteins by regulating autophagy and mitochondrial dynamics, which potentially prevented the kidney and liver from accumulating pathogenic proteins and dysfunctional mitochondria, which alleviated the progression of DN.

摘要

糖尿病肾病（DN）是一种糖尿病并发症，其特征是白蛋白尿和肾小球滤过率下降。糖尿病肾脏在自噬过程和线粒体功能方面存在缺陷，而增强其活性可以减轻病理学损伤。在本文中，我们通过单侧肾切除术后联合高脂肪饮食和链脲佐菌素处理以及补充 （AM）的花或叶提取物，建立了一种 DN 小鼠模型。我们测试了提取物对 DN 病理学以及自噬和线粒体蛋白变化的预防作用。DN 小鼠的空腹血糖、血浆肌酐、血尿素氮和尿白蛋白水平显著升高。糖尿病肾脏的过碘酸希夫和天狼猩红染色显示肾小球和肾小管结构发生了显著变化，与足细胞丢失和纤维蛋白积累有关。AM 提取物处理可减轻 DN 小鼠的这些变化。此外，AM 提取物还可减轻 DN 小鼠的肝损伤、促炎细胞因子和脂质积累。作为一种保护机制，AM 提取物通过调节自噬和线粒体动力学显著增加了蛋白质的表达，这可能防止了肾脏和肝脏积累致病蛋白和功能失调的线粒体，从而缓解了 DN 的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4299/6266484/9085b0bdcb7d/nutrients-10-01703-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4299/6266484/a3c3d17679b9/nutrients-10-01703-g0A1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4299/6266484/3b94ff3e511c/nutrients-10-01703-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4299/6266484/931688cbf766/nutrients-10-01703-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4299/6266484/166e6cc5f7d2/nutrients-10-01703-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4299/6266484/b5bbf3b33628/nutrients-10-01703-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4299/6266484/2ebdf91886a7/nutrients-10-01703-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4299/6266484/9085b0bdcb7d/nutrients-10-01703-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4299/6266484/a3c3d17679b9/nutrients-10-01703-g0A1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4299/6266484/3b94ff3e511c/nutrients-10-01703-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4299/6266484/931688cbf766/nutrients-10-01703-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4299/6266484/166e6cc5f7d2/nutrients-10-01703-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4299/6266484/b5bbf3b33628/nutrients-10-01703-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4299/6266484/2ebdf91886a7/nutrients-10-01703-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4299/6266484/9085b0bdcb7d/nutrients-10-01703-g006.jpg

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Evaluation of the efficacy of (L.) on diabetic nephropathy by analyzing biomarkers in the glomeruli and proximal and distal convoluted tubules of the kidneys.通过分析肾脏肾小球以及近端和远端曲管中的生物标志物来评估（L.）对糖尿病肾病的疗效。
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