Verma Rohit, Kumar Nand, Kumar Saurabh
Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India.
Indian J Psychiatry. 2018 Jul-Sep;60(3):329-333. doi: 10.4103/psychiatry.IndianJPsychiatry_182_16.
There is limited number of studies from India investigating role of repetitive transcranial magnetic stimulation (rTMS) in treatment-resistant depression (TRD). This clinic-based study reports on the efficacy of rTMS as an add-on treatment in patients suffering from TRD.
Twenty-two right-handed patients suffering from major depressive disorder who failed to respond to adequate trials of at least two antidepressants drugs in the current episode received rTMS as an augmenting treatment. High-frequency (Hf) rTMS at 110% of the estimated resting motor threshold (MT) was given over the left dorsolateral prefrontal cortex (DLPFC). A total of 15 sessions were given over 3 weeks with 3000 pulses per session. The outcome was assessed based on the changes in scores of Hamilton Rating Scale for Depression or Montgomery-Asberg Depression Rating Scale.
There was a significant reduction in final assessment scores after rTMS intervention as compared to baseline with almost 50% of the participants showing response in either scale.
Hf rTMS applied over left DLPFC is an effective add-on treatment strategy in patients with TRD.
来自印度的研究中，调查重复经颅磁刺激（rTMS）在难治性抑郁症（TRD）治疗中作用的研究数量有限。这项基于临床的研究报告了rTMS作为TRD患者附加治疗的疗效。
22名右利手的重度抑郁症患者，在当前发作中对至少两种抗抑郁药物的充分试验均无反应，接受rTMS作为强化治疗。在左侧背外侧前额叶皮质（DLPFC）给予估计静息运动阈值（MT）110%的高频（Hf）rTMS。在3周内共进行15次治疗，每次治疗3000个脉冲。根据汉密尔顿抑郁量表或蒙哥马利-阿斯伯格抑郁量表评分的变化评估结果。
与基线相比，rTMS干预后的最终评估得分显著降低，近50%的参与者在任一量表上显示有反应。
在左侧DLPFC应用Hf rTMS是TRD患者有效的附加治疗策略。
