Cattaneo Gabriele, Bartrés-Faz David, Morris Timothy P, Sánchez Javier Solana, Macià Dídac, Tarrero Clara, Tormos Josep M, Pascual-Leone Alvaro
Institut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, Spain.
Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
Front Aging Neurosci. 2018 Oct 11;10:321. doi: 10.3389/fnagi.2018.00321. eCollection 2018.
The Barcelona Brain Health Initiative (BBHI) is an ongoing prospective longitudinal study focused on identifying determinants of brain health. The main objectives are: (i) to characterize lifestyle, cognitive, behavioral and environmental markers related to a given individual's cognitive and mental functions in middle to old age, (ii) to assess the biological determinants predictive of maintenance of brain health, and (iii) to evaluate the impact of a controlled multi-dimensional lifestyle intervention on improving and maintaining brain health. The BBHI cohort consists of >4500 healthy participants aged 40-65 years followed through online questionnaires (Phase I) assessing participants' self-perceived health and lifestyle factors in seven different domains: overall health, physical exercise, cognitive activity, sleep, nutrition, social interactions, and life purpose. In Phase II a sub-group of 1,000 individuals is undergoing detailed in-person evaluations repeated at two-yearly intervals. These evaluations will provide deep phenotyping of brain function, including medical, neurological and psychiatric examinations, assessment of physical fitness, neuropsychological assessments, structural and functional brain magnetic resonance imaging, electroencephalography and perturbation-based non-invasive brain stimulation evaluations of brain activity, as well as collection of biological samples. Finally, in Phase III a further sub-group of 500 participants will undergo a similar in-person assessment before and after a multi-dimensional intervention to optimize lifestyle habits and evaluate its effects on cognitive and brain structure and function. The intervention group will receive remote supervision through an ICT-based solution, with the support of an expert in health and lifestyle coaching strategies aimed at promoting adherence. On the other hand, the control group will not have this coaching support, and will only receive education and recommendations about healthy habits. Results of this three-part initiative shall critically contribute to a better understanding of the determinants to promote and maintain brain health over the lifespan.
巴塞罗那脑健康倡议（BBHI）是一项正在进行的前瞻性纵向研究，专注于确定脑健康的决定因素。主要目标包括：（i）描述与个体中年至老年认知和心理功能相关的生活方式、认知、行为和环境标志物；（ii）评估预测脑健康维持的生物学决定因素；（iii）评估多维生活方式干预对改善和维持脑健康的影响。BBHI队列由4500多名40至65岁的健康参与者组成，通过在线问卷（第一阶段）跟踪，该问卷评估参与者在七个不同领域的自我感知健康和生活方式因素：总体健康、体育锻炼、认知活动、睡眠、营养、社交互动和生活目标。在第二阶段，1000名个体的子组每两年接受一次详细的面对面评估。这些评估将提供脑功能的深度表型分析，包括医学、神经学和精神科检查、体能评估、神经心理学评估、脑结构和功能磁共振成像、脑电图以及基于微扰的无创脑刺激脑活动评估，以及生物样本的采集。最后，在第三阶段，500名参与者的另一个子组将在多维干预前后接受类似的面对面评估，以优化生活方式习惯并评估其对认知以及脑结构和功能的影响。干预组将通过基于信息通信技术的解决方案接受远程监督，并得到健康和生活方式指导策略专家的支持，以促进依从性。另一方面，对照组将不接受这种指导支持，仅接受关于健康习惯的教育和建议。这一分为三个部分的倡议结果将对更好地理解在整个生命周期中促进和维持脑健康的决定因素做出重要贡献。
