慢性酒精治疗诱导的GABA-Aα5组蛋白H3K4三甲基化上调导致Wistar大鼠后代中GABA-Aα5表达增加及酒精成瘾易感性增强。
Chronic Alcohol Treatment-Induced GABA-Aα5 Histone H3K4 Trimethylation Upregulation Leads to Increased GABA-Aα5 Expression and Susceptibility to Alcohol Addiction in the Offspring of Wistar Rats.
作者信息
Zeng Kuan, Xie Aimin, Zhang Xiaojie, Zhong Baoliang, Liu Xuebing, Hao Wei
机构信息
Research Center for Psychological and Health Sciences, China University of Geosciences, Wuhan, China.
Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science & Technology, Wuhan, China.
出版信息
Front Psychiatry. 2018 Oct 24;9:468. doi: 10.3389/fpsyt.2018.00468. eCollection 2018.
Abstract
Gamma-aminobutyric acid (GABA)-Aα5 is considered to be associated with alcohol-induced memory deficits. However, whether it participates in the formation of alcohol addiction or in the regulation of its susceptibility is unknown. Here, we used a chronic alcohol treatment model to obtain alcohol-addicted Wistar rats. Long-term alcoholism increased the expression of prefrontal cortex GABA-Aα5 by inducing its histone H3K4 trimethylation, and these changes could be hereditary and lead to increased vulnerability to alcohol addiction in offspring. This study indicates the risk of long-term alcoholism in future generations, emphasizes the importance of GABA-Aα5 in the formation of alcohol addiction and the regulation of its susceptibility, and provides new evidence regarding the mechanisms underlying alcohol addiction.
摘要
γ-氨基丁酸（GABA）-Aα5被认为与酒精引起的记忆缺陷有关。然而，它是否参与酒精成瘾的形成或对其易感性的调节尚不清楚。在此，我们使用慢性酒精处理模型获得酒精成瘾的Wistar大鼠。长期酗酒通过诱导前额叶皮质GABA-Aα5的组蛋白H3K4三甲基化增加了其表达，并且这些变化可能具有遗传性并导致后代对酒精成瘾的易感性增加。本研究表明了后代长期酗酒的风险，强调了GABA-Aα5在酒精成瘾形成及其易感性调节中的重要性，并为酒精成瘾的潜在机制提供了新证据。
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