College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China.
Department of Medical Science and Public Health, Faculty of Medical Science, Anglia Ruskin University, Chelmsford CM1 1SQ, UK.
J Healthc Eng. 2018 Oct 11;2018:1308419. doi: 10.1155/2018/1308419. eCollection 2018.
Arterial pulse wave analysis has been attempted to monitor the maternal physiological changes of circulatory system during pregnancy. This study aimed to quantify the difference of Gaussian modelling characteristics derived from radial pulses measured from the three trimesters of healthy pregnant women. Radial pulses were recorded from seventy pregnant women between gestational week 11-13, week 20-22, and then week 37-39. They were then normalized and decomposed into three independent Gaussian waves for deriving four key modelling characteristic parameters: including the peak time interval () and peak amplitude ratio () between the first and second Gaussian waves ( and ), and their corresponding values between the first and third Gaussian waves ( and ). Post hoc multiple comparisons after analysis of variance was then applied to study the within-subject differences in Gaussian modelling characteristics between the three trimesters. The key results were that and increased significantly ( : 12.8 ± 1.3 vs 13.2 ± 1.3, < 0.05; : 39.5 ± 4.3 vs 45.4 ± 5.1, < 0.001), and decreased significantly from the first to second trimester (0.60 ± 0.15 vs 0.53 ± 0.11, < 0.001). From the second to third trimester, decreased significantly (13.2 ± 1.3 vs 12.8 ± 1.2, < 0.01), and and decreased slightly but nonsignificantly. Since larger and and smaller are associated with more compliant peripheral arteries, our results indicated that peripheral arteries become more compliant from the first to second trimester and then have a tendency of returning to baseline during normal pregnancy. In conclusion, this study has quantitatively demonstrated significant changes of Gaussian modelling characteristics derived from radial pulses at the three trimesters of normal pregnant women, suggesting that these modelling characteristics could be used as parameters in monitoring maternal physiological changes during normal pregnancy.
动脉脉搏波分析已被尝试用于监测妊娠期间循环系统的母体生理变化。本研究旨在量化从健康孕妇的三个孕期（妊娠 11-13 周、20-22 周和 37-39 周）测量的桡动脉得出的高斯建模特征的差异。从 70 名孕妇中记录桡动脉搏动，然后将其归一化并分解为三个独立的高斯波，以得出四个关键建模特征参数：包括第一和第二高斯波之间的峰时间间隔（）和峰幅度比（）（和），以及第一和第三高斯波之间的对应值（和）。然后应用方差分析后的事后多重比较来研究三个孕期之间高斯建模特征的个体内差异。主要结果是：和显著增加（：12.8±1.3 vs 13.2±1.3，<0.05；：39.5±4.3 vs 45.4±5.1，<0.001），从第一孕期到第二孕期显著降低（0.60±0.15 vs 0.53±0.11，<0.001）。从第二孕期到第三孕期，显著降低（13.2±1.3 vs 12.8±1.2，<0.01），和略有但无统计学意义的降低。由于较大的和较小的表示外周动脉顺应性增加，我们的结果表明，外周动脉从第一孕期到第二孕期变得更加顺应，然后在正常妊娠期间有回归基线的趋势。总之，本研究定量证明了来自正常孕妇三个孕期的桡动脉得出的高斯建模特征的显著变化，表明这些建模特征可作为监测正常妊娠期间母体生理变化的参数。
