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吡非尼酮可能导致播散性水痘-带状疱疹病毒感染伴腹痛：一例报告。

Disseminated varicella-zoster virus infection with abdominal pain possibly caused by pirfenidone: A case report.

作者信息

Shiroshita Akihiro, Nakashima Kei, Aoshima Masahiro

机构信息

Department of Pulmonary Medicine, Kameda Medical Center, 929 Higashi-cho, Kamogawa, Chiba 296-8602, Japan.

出版信息

Respir Med Case Rep. 2018 Oct 26;25:330-332. doi: 10.1016/j.rmcr.2018.10.023. eCollection 2018.

DOI:10.1016/j.rmcr.2018.10.023
PMID:30406013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6214882/
Abstract

We report a case of chronic hypersensitivity pneumonitis treated with pirfenidone in a 76-year-old woman who complained of acute-onset abdominal pain and rashes. The patient was diagnosed with disseminated varicella-zoster virus (VZV) infection, and pirfenidone was discontinued. Her condition improved in one month. Pirfenidone may induce disseminated VZV infection.

摘要

我们报告了一例76岁女性慢性过敏性肺炎患者，该患者使用吡非尼酮治疗，出现急性腹痛和皮疹。患者被诊断为播散性水痘-带状疱疹病毒（VZV）感染，吡非尼酮停药。患者病情在一个月内好转。吡非尼酮可能诱发播散性VZV感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6156/6214882/78f01009ef64/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6156/6214882/78f01009ef64/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6156/6214882/78f01009ef64/gr1.jpg

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本文引用的文献

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Pirfenidone: a review of its use in idiopathic pulmonary fibrosis.吡非尼酮：在特发性肺纤维化中的应用评价。
Drugs. 2015 Feb;75(2):219-30. doi: 10.1007/s40265-015-0350-9.
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Review: The neurobiology of varicella zoster virus infection.综述：水痘-带状疱疹病毒感染的神经生物学。
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[Case of visceral varicella-zoster virus infection after autologous peripheral blood stem cell transplantation in which severe abdominal pain preceded the skin rash].
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Am J Transplant. 2007 Apr;7(4):741-7. doi: 10.1111/j.1600-6143.2006.01718.x.
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Visceral varicella zoster virus infection after stem cell transplantation: a possible cause of severe abdominal pain.干细胞移植后内脏水痘带状疱疹病毒感染：严重腹痛的一个可能原因。
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Varicella-Zoster virus pathogenesis and immunobiology: new concepts emerging from investigations with the SCIDhu mouse model.水痘-带状疱疹病毒发病机制与免疫生物学：从SCIDhu小鼠模型研究中涌现的新概念
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7
A case of fatal varicella zoster infection with refractory abdominal pain as an early symptom.一例以难治性腹痛为早期症状的致命性水痘带状疱疹感染病例。
Kansenshogaku Zasshi. 2004 Jan;78(1):64-9. doi: 10.11150/kansenshogakuzasshi1970.78.64.
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[Reactivation of herpes zoster infection by varicella-zoster virus].[水痘-带状疱疹病毒引起的带状疱疹感染再激活]
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