Fan Guohui, Hu Dan, Zhang Xinran, Peng Feng, Lin Xiandong, Chen Gang, Liang Binying, Zhang Hejun, Xia Yan, Zheng Xiongwei, Jie Jianzheng, Niu Wenquan
Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.
Department of Pathology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, China.
Front Oncol. 2018 Oct 23;8:461. doi: 10.3389/fonc.2018.00461. eCollection 2018.
We aimed to investigate the interaction between prediabetes and the ABO blood types in predicting esophageal squamous cell carcinoma (ESCC)-specific mortality by analysing data from the FIESTA study on normal/prediabetic patients with ESCC. Total 1,857 normal/prediabetic patients with ESCC who underwent three-field lymphadenectomy between January 2000 and December 2010 and survived hospitalization were analyzable, with follow-up beginning in 2000 and ending in 2015. At the end of the follow-up, there were 1,161 survivors and 696 non-survivors. The follow-up time ranged from 0.5 to 180 months. The cumulative survival rates in normal patients were obviously better than in prediabetic patients. The cumulative survival rates were significantly higher in normal patients than in prediabetic patients for the blood types O and A (Log-rank test < 0.05), while no significance was detected for the blood types B and AB. Adjusted risk estimates for ESCC-specific mortality for prediabetic patients relative to normal patients were statistically significant in the blood type B group (hazard ratio [HR]: 1.71; 95% confidence interval [CI]: 1.33-2.20; < 0.001), but not in the blood type B group (HR: 1.12; 95% CI: 0.77-1.64; = 0.5544). Our findings indicate that prediabetes can predict the significant risk of ESCC-specific mortality in Chinese Han patients with the blood types O and A.
我们旨在通过分析FIESTA研究中正常/糖尿病前期食管癌（ESCC）患者的数据，研究糖尿病前期与ABO血型之间的相互作用，以预测食管鳞状细胞癌（ESCC）特异性死亡率。共有1857例在2000年1月至2010年12月期间接受了三野淋巴结清扫术且住院存活的正常/糖尿病前期ESCC患者可供分析，随访从2000年开始，至2015年结束。随访结束时，有1161例幸存者和696例非幸存者。随访时间为0.5至180个月。正常患者的累积生存率明显优于糖尿病前期患者。O型和A型血的正常患者累积生存率显著高于糖尿病前期患者（对数秩检验<0.05），而B型和AB型血未检测到显著性差异。糖尿病前期患者相对于正常患者的ESCC特异性死亡率的调整风险估计在B型血组中具有统计学意义（风险比[HR]：1.71；95%置信区间[CI]：1.33 - 2.20；<0.001），但在B型血组中无统计学意义（HR：1.12；95%CI：0.77 - 1.64；=0.5544）。我们的研究结果表明，糖尿病前期可预测中国汉族O型和A型血患者ESCC特异性死亡的显著风险。
