Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China.
Department of Gynecologic Tumor, Shaanxi Province Tumor Hospital, Xi'an, Shaanxi, P. R. China.
Sci Rep. 2017 Jun 30;7(1):4412. doi: 10.1038/s41598-017-04046-4.
ABO blood types are associated with the prognosis of several malignancies. However, the role of the ABO blood type in hepatocellular carcinoma (HCC) remains elusive. Here, we evaluated the prognostic role of the ABO blood group in 691 HCC patients after hepatectomy by Cox regression analysis. A prognostic nomogram was generated to predict the 3 and 5-year overall survival (OS). A total of 262 HCC patients (37.9%) had blood group O, 199 (28.8%) had blood group A, 165 (23.9%) had blood group B, and 65 (9.4%) had blood group AB. The median OS was 55 months in patients with blood group O, 39 months for blood group A, 34 months for blood group B, and 34 months for blood group AB patients (P = 0.001, log-rank test). There were significant differences in OS between patients with blood groups O and A [hazard ratio (HR) = 1.416; 95% CI, 1.101-1.820; P = 0.007], blood group B (HR = 1.736; 95% CI, 1.333-2.262; P < 0.001), blood group AB (HR = 1.739; 95% CI, 1.210-2.499; P = 0.003) and non-O blood groups (HR = 1.485; 95% CI, 1.204-1.830; P < 0.001). Our constructed nomogram (c-index = 0.687) predicted the prognosis more accurately than the TNM stage alone(c-index = 0.601). In conclusion, non-O blood groups are poor prognostic indicators for HCC following hepatectomy. Our findings justify further external validation in larger cohorts.
ABO 血型与多种恶性肿瘤的预后相关。然而，ABO 血型在肝细胞癌（HCC）中的作用仍不清楚。在这里，我们通过 Cox 回归分析评估了 691 例 HCC 患者肝切除术后 ABO 血型的预后作用。生成了一个预测 3 年和 5 年总生存率（OS）的预后列线图。共有 262 例（37.9%）HCC 患者血型为 O，199 例（28.8%）为 A，165 例（23.9%）为 B，65 例（9.4%）为 AB。O 型血患者的中位 OS 为 55 个月，A 型血为 39 个月，B 型血为 34 个月，AB 型血为 34 个月（P=0.001，对数秩检验）。O 型血与 A 型血（HR=1.416；95%CI，1.101-1.820；P=0.007）、B 型血（HR=1.736；95%CI，1.333-2.262；P<0.001）、AB 型血（HR=1.739；95%CI，1.210-2.499；P=0.003）和非 O 型血（HR=1.485；95%CI，1.204-1.830；P<0.001）之间的 OS 存在显著差异。我们构建的列线图（c 指数=0.687）比单独的 TNM 分期（c 指数=0.601）更准确地预测预后。总之，非 O 型血是 HCC 肝切除术后预后不良的指标。我们的发现证明在更大的队列中进一步进行外部验证是合理的。
