School of Chinese Medicine, China Medical University, Taichung, Taiwan.
Department of Nursing, National Taichung University of Science and Technology, Taichung, Taiwan.
Biomed Res Int. 2018 Oct 14;2018:9531315. doi: 10.1155/2018/9531315. eCollection 2018.
Oral squamous cell carcinoma (OSCC) accounts for over 90% of malignant neoplasms of the mouth. In Taiwan, OSCC is the fourth most common male cancer and the fourth leading cause of male cancer death. Resistin () is an adipokine that is associated with obesity, inflammation, and various cancers. Here, we examine the association between four single nucleotide polymorphisms (SNPs) of the gene (rs3745367, rs7408174, rs1862513, and rs3219175) and OSCC susceptibility as well as clinical outcomes in 935 patients with OSCC and in 1200 cancer-free healthy controls. We found that, in 1465 smokers, polymorphisms carriers with the betel-nut chewing habit had a 6.708-10.882-fold greater risk of having OSCC compared to wild-type carriers without the betel-nut chewing habit. Patients with OSCC who had A/A homozygous of rs3219175 polymorphism showed a high risk for an advanced tumor size (> T2), compared to those patients with G/G homozygotes. In addition, A/T/G/G haplotype significantly increased the risks for OSCC by 1.376-fold. This study is the first to examine the risk factors associated with SNPs in OSCC progression and development in Taiwan.
口腔鳞状细胞癌（OSCC）占口腔恶性肿瘤的 90%以上。在台湾，OSCC 是男性第四大常见癌症，也是男性癌症死亡的第四大主要原因。抵抗素（）是一种与肥胖、炎症和各种癌症相关的脂肪因子。在这里，我们研究了基因（rs3745367、rs7408174、rs1862513 和 rs3219175）的四个单核苷酸多态性（SNP）与 935 例 OSCC 患者和 1200 例无癌症健康对照者的 OSCC 易感性及临床结局的关系。我们发现，在 1465 名吸烟者中，与不嚼槟榔的野生型携带者相比，携带 多态性且有嚼槟榔习惯的个体患 OSCC 的风险增加了 6.708-10.882 倍。与 G/G 纯合子相比，OSCC 患者 rs3219175 基因 A/A 纯合子的患者肿瘤体积较大（> T2）的风险较高。此外，A/T/G/G 单倍型显著增加了 1.376 倍的 OSCC 发病风险。本研究首次在台湾地区探讨了与 OSCC 进展和发展相关的 基因 SNP 的危险因素。
