Department of Thoracic Surgery, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.
Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan.
Int J Med Sci. 2017 Sep 19;14(12):1197-1202. doi: 10.7150/ijms.20933. eCollection 2017.
Lung cancer is one of the most frequently diagnosed malignancies and is associated with a poor survival rate in the Chinese Han population. Analysis of genetic variants could lead to improvements in prognosis following lung cancer therapy. High-mobility group box 1 protein (HMGB1) is a ubiquitous nuclear protein found in eukaryotic cells that participates in several biological functions including immune response, cell survival, apoptosis and cancer development. We investigated the effects of gene polymorphisms on the risk of lung cancer progression in a Chinese Han population. Our sample of 751 participants included 372 patients with lung cancer and 379 healthy controls. Four single-nucleotide polymorphisms (SNPs) of the gene were examined by real-time polymerase chain reaction (RT-PCR). We found that the CT or CC+CT heterozygotes of the rs1045411 polymorphism reduced the risks for lung cancer, while the G/T/C haplotypes of three SNPs (rs1360485, rs1045411 and rs2249825) also reduced the risk for lung cancer by almost half (0.486-fold). The current study is the first to examine the risk factors associated with SNPs in lung cancer development in the Chinese Han population.
肺癌是最常见的恶性肿瘤之一，在中国汉族人群中与生存率低有关。对遗传变异的分析可能会导致肺癌治疗后的预后改善。高迁移率族蛋白 1（HMGB1）是一种广泛存在于真核细胞中的核蛋白，参与多种生物学功能，包括免疫反应、细胞存活、凋亡和癌症发展。我们研究了基因多态性对中国汉族人群肺癌进展风险的影响。我们的 751 名参与者样本包括 372 名肺癌患者和 379 名健康对照者。通过实时聚合酶链反应（RT-PCR）检测了 基因的 4 个单核苷酸多态性（SNP）。我们发现，基因 rs1045411 多态性的 CT 或 CC+CT 杂合子降低了肺癌的风险，而三个 SNP(rs1360485、rs1045411 和 rs2249825)的 G/T/C 单倍型也使肺癌的风险降低了近一半（0.486 倍）。本研究首次在中国汉族人群中研究了与肺癌发生相关的 基因多态性的危险因素。
