A successful treatment with 5 methyltetrahydrofolate of a 677 TT MTHFR woman suffering premature ovarian insufficiency post a NHL (non-Hodgkin's lymphoma) and RPL (repeat pregnancy losses).
作者信息
Goyco Ortiz Luz E, Servy Edouard J, Menezo Yves J R
机构信息
Servy Institute of Reproductive Endocrinology, 812 Chafee Avenue, Augusta, GA, 30904, USA.
Laboratoire Clement, Avenue d 'Eylau, Paris, France.
出版信息
J Assist Reprod Genet. 2019 Jan;36(1):65-67. doi: 10.1007/s10815-018-1332-0. Epub 2018 Nov 8.
Abstract
摘要
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A successful treatment with 5 methyltetrahydrofolate of a 677 TT MTHFR woman suffering premature ovarian insufficiency post a NHL (non-Hodgkin's lymphoma) and RPL (repeat pregnancy losses).一名患有677 TT型亚甲基四氢叶酸还原酶（MTHFR）的女性，在非霍奇金淋巴瘤（NHL）和复发性流产（RPL）后出现卵巢早衰，用5-甲基四氢叶酸治疗成功。
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Mefolinate (5-methyltetrahydrofolate), but not folic acid, decreases mortality in an animal model of severe methylenetetrahydrofolate reductase deficiency.亚叶酸（5-甲基四氢叶酸）而非叶酸，可降低严重亚甲基四氢叶酸还原酶缺乏动物模型的死亡率。
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5-Methyltetrahydrofolate reduces blood homocysteine level significantly in C677T methyltetrahydrofolate reductase single-nucleotide polymorphism carriers consulting for infertility.5-甲基四氢叶酸可显著降低因不育前来咨询的C677T甲基四氢叶酸还原酶单核苷酸多态性携带者的血液同型半胱氨酸水平。
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High doses of folic acid induce a pseudo-methylenetetrahydrofolate syndrome.高剂量叶酸会诱发假性亚甲基四氢叶酸综合征。
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A paternal effect of MTHFR SNPs on gametes and embryos should not be overlooked: case reports.亚甲基四氢叶酸还原酶单核苷酸多态性对配子和胚胎的父系效应不应被忽视：病例报告。
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本文引用的文献
1
High doses of folic acid induce a pseudo-methylenetetrahydrofolate syndrome.高剂量叶酸会诱发假性亚甲基四氢叶酸综合征。
SAGE Open Med Case Rep. 2019 May 17;7:2050313X19850435. doi: 10.1177/2050313X19850435. eCollection 2019.
2
MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs folic acid: a key to pregnancy outcome: a case series.MTHFR 同工型携带者。5-MTHF（5-甲基四氢叶酸）与叶酸：妊娠结局的关键：病例系列。
J Assist Reprod Genet. 2018 Aug;35(8):1431-1435. doi: 10.1007/s10815-018-1225-2. Epub 2018 Jun 7.
3
Supporting the One-Carbon Cycle Restores Ovarian Reserve in Subfertile Women: Absence of Correlation with Urinary Bisphenol A Concentration.支持一碳循环可恢复亚生育力女性的卵巢储备：与尿中双酚A浓度无关。
Biores Open Access. 2017 Aug 1;6(1):104-109. doi: 10.1089/biores.2017.0016. eCollection 2017.
4
Improvement of gamete quality by stimulating and feeding the endogenous antioxidant system: mechanisms, clinical results, insights on gene-environment interactions and the role of diet.通过刺激和滋养内源性抗氧化系统改善配子质量：机制、临床结果、对基因-环境相互作用的见解以及饮食的作用
J Assist Reprod Genet. 2016 Dec;33(12):1633-1648. doi: 10.1007/s10815-016-0767-4. Epub 2016 Jul 16.
5
Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy.MTHFR 基因多态性影响胚胎活力和非整倍体发生率。
Hum Genet. 2016 May;135(5):555-568. doi: 10.1007/s00439-016-1652-z. Epub 2016 Apr 11.
6
Maternal DNA Methylation Regulates Early Trophoblast Development.母体DNA甲基化调节早期滋养层细胞发育。
Dev Cell. 2016 Jan 25;36(2):152-63. doi: 10.1016/j.devcel.2015.12.027.
7
Association between maternal, fetal and paternal MTHFR gene C677T and A1298C polymorphisms and risk of recurrent pregnancy loss: a comprehensive evaluation.母体、胎儿和父体亚甲基四氢叶酸还原酶（MTHFR）基因C677T和A1298C多态性与复发性流产风险的关联：一项综合评估
Arch Gynecol Obstet. 2016 Jun;293(6):1197-211. doi: 10.1007/s00404-015-3944-2. Epub 2015 Nov 3.
8
MTHFR 677C>T polymorphism increases the male infertility risk: a meta-analysis involving 26 studies.亚甲基四氢叶酸还原酶（MTHFR）677C>T基因多态性增加男性不育风险：一项纳入26项研究的荟萃分析
PLoS One. 2015 Mar 20;10(3):e0121147. doi: 10.1371/journal.pone.0121147. eCollection 2015.
9
Association of MTHFR C677T and A1298C polymorphisms with non-Hodgkin lymphoma susceptibility: evidence from a meta-analysis.亚甲基四氢叶酸还原酶（MTHFR）C677T和A1298C基因多态性与非霍奇金淋巴瘤易感性的关联：一项荟萃分析的证据
Sci Rep. 2014 Aug 22;4:6159. doi: 10.1038/srep06159.
10
Impact of DNA methylation on trophoblast function.DNA 甲基化对滋养层功能的影响。
Clin Epigenetics. 2011 Nov 1;3(1):7. doi: 10.1186/1868-7083-3-7.
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