AcSIR and Natural Product Microbes , CSIR-Indian Institute of Integrative Medicine , Jammu - 180001 , India.
Department of Chemistry , University of Kashmir , Srinagar 190006 , India.
J Org Chem. 2018 Dec 7;83(23):14443-14456. doi: 10.1021/acs.joc.8b02193. Epub 2018 Nov 21.
A photoredox catalyzed approach enabling use of alkynes as surrogate of 2-oxoaldehydes/1,2-diones is reported. The method overcomes the difficulty associated with application of unsubstituted aliphatic α-oxoaldehydes, which has hitherto limited their general use. Indoles, tryptamine, and tryptophan methyl ester participated in the reaction to give a variety of α-oxo based analogues. Quantum yield investigations support a radical chain mechanism.
本文报道了一种光氧化还原催化方法，可使炔烃替代 2-氧代醛/1,2-二酮使用。该方法克服了应用未取代的脂肪族α-氧代醛所带来的困难，这一困难限制了它们的广泛应用。吲哚、色胺和色氨酸甲酯参与反应，生成了多种基于α-氧酮的类似物。量子产率研究支持自由基链反应机制。
