Primahana Gian, Risdian Chandra, Mozef Tjandrawati, Sudarman Enge, Köck Matthias, Wink Joachim, Stadler Marc
Department Microbial Drugs, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstrasse 7, 38124 Braunschweig, Germany.
Research Center for Chemistry, Indonesian Institute of Sciences (LIPI), Kawasan Puspiptek, Serpong, 15314 Tangerang Selatan, Indonesia.
Antibiotics (Basel). 2020 Mar 17;9(3):126. doi: 10.3390/antibiotics9030126.
During the course of our ongoing screening for novel biologically active secondary metabolites, the rare Actinobacterium, sp. 1808210CR was found to produce five unprecedented -carboline derivatives, nonocarbolines A-E (). Their structures were elucidated from high-resolution mass spectrometry, 1D and 2D nuclear magnetic resonance spectroscopy, and the absolute configuration of was determined by using the modified Mosher method. Nonocarboline B () displayed moderate antifungal activity against , while nonocarboline D () exhibited significant cytotoxic activity against the human lung carcinoma cell line A-549 with the IC value of 1.7 µM.
在我们持续筛选新型生物活性次生代谢产物的过程中，发现稀有放线菌sp. 1808210CR能产生五种前所未有的β-咔啉衍生物，即九咔啉A-E（）。通过高分辨率质谱、一维和二维核磁共振光谱对其结构进行了阐明，并使用改良的莫舍尔方法确定了的绝对构型。九咔啉B（）对显示出中等抗真菌活性，而九咔啉D（）对人肺癌细胞系A-549表现出显著的细胞毒性活性，IC值为1.7 μM。
