Losno Marion, Ferrante Ivan, Brennetot René, Varlet Jérôme, Blanc Cécile, Grenut Bernard, Amblard Etienne, Descroix Stéphanie, Mariet Clarisse
Den-Service d'Etudes Analytiques et de Réactivité des Surfaces (SEARS), CEA, Université Paris-Saclay, F-91191 Gif sur Yvette, France.
MMBM Group, Institut Curie Research Center, CNRS UMR 168, F-75005 Paris, France.
Micromachines (Basel). 2016 Mar 10;7(3):45. doi: 10.3390/mi7030045.
The use of a centrifugal microfluidic platform is an alternative to classical chromatographic procedures for radiochemistry. An ion-exchange support with respect to the light-addressable process of elaboration is specifically designed to be incorporated as a radiochemical sample preparation module in centrifugal microsystem devices. This paper presents a systematic study of the synthesis of the polymeric porous monolith poly(ethylene glycol methacrylate-co-allyl methacrylate) used as a solid-phase support and the versatile and robust photografting process of the monolith based on thiol-ene click chemistry. The polymerization reaction is investigated, varying the formulation of the polymerisable mixture. The robustness of the stationary phase was tested in concentrated nitric acid. Thanks to their unique "easy-to-use" features, centrifugal microfluidic platforms are potential successful candidates for the downscaling of chromatographic separation of radioactive samples (automation, multiplexing, easy integration in glove-boxes environment, and low cost of maintenance).
使用离心微流控平台是放射化学中经典色谱程序的一种替代方法。针对光寻址制备过程的离子交换载体经过专门设计，可作为放射化学样品制备模块集成到离心微系统装置中。本文对用作固相载体的聚合多孔整体材料聚（甲基丙烯酸乙二醇酯 - 甲基丙烯酸烯丙酯）的合成以及基于硫醇 - 烯点击化学的整体材料通用且稳健的光接枝过程进行了系统研究。研究了聚合反应，改变了可聚合混合物的配方。在浓硝酸中测试了固定相的稳定性。由于其独特的“易于使用”特性，离心微流控平台是放射性样品色谱分离小型化（自动化、多路复用、易于集成到手套箱环境以及维护成本低）的潜在成功候选者。
