Department of Animal Science, The Pennsylvania State University, University Park, PA 16802, USA.
Poult Sci. 2019 Apr 1;98(4):1762-1765. doi: 10.3382/ps/pey507.
Fibroblast growth factor 23 (FGF-23) is proposed to be the hormone that controls phosphate (P) homeostasis in chickens. This study was initiated to investigate the effect of feeding young chicks diets that were either adequate (0.45%) or marginal (0.25%) in available P content on plasma FGF-23 levels. The dietary level of available P significantly (P ≤ 0.05) affected bone mineralization and bone length, but was without effect (P > 0.05) on growth rate and circulating FGF-23 concentrations. Substantial individual variation in bone mineralization and plasma FGF-23 levels was observed, and the correlation between these two variables was non-significant (P > 0.05). This suggested that there was no alteration in FGF-23 activity in response to suboptimal dietary P intake. The relationship of these observations to studies on the immunosuppression of FGF-23 activity is subsequentlydiscussed.
成纤维细胞生长因子 23（FGF-23）被认为是控制鸡体内磷酸盐（P）稳态的激素。本研究旨在研究为幼鸡提供充足（0.45%）或边缘（0.25%）有效磷含量的饮食对血浆 FGF-23 水平的影响。有效磷的膳食水平显著（P≤0.05）影响骨矿化和骨长度，但对生长速度和循环 FGF-23 浓度没有影响（P＞0.05）。观察到骨矿化和血浆 FGF-23 水平存在很大的个体差异，这两个变量之间的相关性不显著（P＞0.05）。这表明，在应对低磷饮食时，FGF-23 活性没有发生改变。随后讨论了这些观察结果与 FGF-23 活性免疫抑制研究的关系。
