证据表明 FGF23 参与了一个骨-肾轴的调节，该轴调节骨矿物质化和全身磷酸盐及维生素 D 稳态。
Evidence for FGF23 involvement in a bone-kidney axis regulating bone mineralization and systemic phosphate and vitamin D homeostasis.
机构信息
Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
出版信息
Adv Exp Med Biol. 2012;728:65-83. doi: 10.1007/978-1-4614-0887-1_4.
Abstract
Bone is involved in the maintenance of phosphate and vitamin D homeostasis via its production and secretion of FGF23 and serves as a reservoir for the storage and release of calcium and phosphate into the circulation. Alterations in mineralization of extracellular matrix and the remodeling activities of the skeleton are coupled to the kidney conservation of phosphate and production of 1,25(OH)2D via the regulation of FGF23 production by osteocytes through yet-to-be defined locally derived factors. In addition, FGF23 production is regulated by 1,25(OH)2D in a feedback loop where FGF23 stimulate Cyp24 mediated degradation of 1,25(OH)2D that serves to protect the organism from the toxic effects of vitamin D excess. In this chapter, we will review the regulation and function of FGF23.
摘要
骨骼通过产生和分泌 FGF23 来参与维持磷酸盐和维生素 D 的体内平衡，并作为钙和磷酸盐在循环中储存和释放的储库。细胞外基质矿化和骨骼重塑活动的改变与肾脏通过成骨细胞产生的 FGF23 调节磷酸盐的保留和 1,25(OH)2D 的产生有关，这种调节是通过尚未确定的局部来源因子进行的。此外，FGF23 的产生受 1,25(OH)2D 的反馈调节，FGF23 刺激 Cyp24 介导的 1,25(OH)2D 降解，从而保护机体免受维生素 D 过量的毒性作用。在本章中，我们将回顾 FGF23 的调节和功能。
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