The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Nucleic Acids Res. 2019 Jan 8;47(D1):D801-D806. doi: 10.1093/nar/gky1056.
The Mouse Genome Database (MGD; http://www.informatics.jax.org) is the community model organism genetic and genome resource for the laboratory mouse. MGD is the authoritative source for biological reference data sets related to mouse genes, gene functions, phenotypes, and mouse models of human disease. MGD is the primary outlet for official gene, allele and mouse strain nomenclature based on the guidelines set by the International Committee on Standardized Nomenclature for Mice. In this report we describe significant enhancements to MGD, including two new graphical user interfaces: (i) the Multi Genome Viewer for exploring the genomes of multiple mouse strains and (ii) the Phenotype-Gene Expression matrix which was developed in collaboration with the Gene Expression Database (GXD) and allows researchers to compare gene expression and phenotype annotations for mouse genes. Other recent improvements include enhanced efficiency of our literature curation processes and the incorporation of Transcriptional Start Site (TSS) annotations from RIKEN's FANTOM 5 initiative.
鼠标基因组数据库（MGD；http://www.informatics.jax.org）是实验室老鼠的社区模式生物遗传和基因组资源。MGD 是与老鼠基因、基因功能、表型和人类疾病的老鼠模型相关的生物参考数据集的权威来源。MGD 是基于国际标准化命名委员会为老鼠设定的准则发布官方基因、等位基因和老鼠品系命名的主要渠道。在本报告中，我们描述了 MGD 的重大改进，包括两个新的图形用户界面：（i）多基因组浏览器，用于探索多个老鼠品系的基因组；（ii）表型-基因表达矩阵，这是与基因表达数据库（GXD）合作开发的，允许研究人员比较老鼠基因的基因表达和表型注释。其他最近的改进包括提高我们文献注释过程的效率，并整合 RIKEN 的 FANTOM 5 计划的转录起始位点（TSS）注释。
