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iPLAβ and its role in male fertility, neurological disorders, metabolic disorders, and inflammation.iPLAβ 及其在男性生育力、神经紊乱、代谢紊乱和炎症中的作用。
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jun;1864(6):846-860. doi: 10.1016/j.bbalip.2018.10.010. Epub 2018 Nov 5.
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Calcium-independent phospholipases A2 and their roles in biological processes and diseases.不依赖钙的磷脂酶A2及其在生物过程和疾病中的作用。
J Lipid Res. 2015 Sep;56(9):1643-68. doi: 10.1194/jlr.R058701. Epub 2015 May 28.
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The Impact of the Ca-Independent Phospholipase Aβ (iPLAβ) on Immune Cells.钙非依赖性磷脂酶 Aβ（iPLAβ）对免疫细胞的影响。
Biomolecules. 2021 Apr 15;11(4):577. doi: 10.3390/biom11040577.
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Analyses of Calcium-Independent Phospholipase Abeta (iPLAβ) in Biological Systems.生物系统中钙非依赖性磷脂酶Aβ（iPLAβ）的分析
Methods Enzymol. 2017;583:119-141. doi: 10.1016/bs.mie.2016.09.001. Epub 2016 Oct 18.
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The molecular biology of the group VIA Ca2+-independent phospholipase A2.VI A 组钙离子非依赖性磷脂酶A2的分子生物学
Prog Nucleic Acid Res Mol Biol. 2001;67:1-33. doi: 10.1016/s0079-6603(01)67023-5.
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Studies of insulin secretory responses and of arachidonic acid incorporation into phospholipids of stably transfected insulinoma cells that overexpress group VIA phospholipase A2 (iPLA2beta ) indicate a signaling rather than a housekeeping role for iPLA2beta.对稳定转染并过表达ⅥA 组磷脂酶 A2（iPLA2β）的胰岛素瘤细胞的胰岛素分泌反应以及花生四烯酸掺入磷脂的研究表明，iPLA2β具有信号传导而非管家功能。
J Biol Chem. 2001 Apr 20;276(16):13198-208. doi: 10.1074/jbc.M010423200. Epub 2001 Jan 22.
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Macrophage polarization is linked to Ca-independent phospholipase Aβ-derived lipids and cross-cell signaling in mice.巨噬细胞极化与 Ca 非依赖性磷脂酶 Aβ衍生脂质和小鼠中的细胞间信号转导有关。
J Lipid Res. 2020 Feb;61(2):143-158. doi: 10.1194/jlr.RA119000281. Epub 2019 Dec 9.
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The expression and function of a group VIA calcium-independent phospholipase A2 (iPLA2beta) in beta-cells.VIA组钙离子非依赖性磷脂酶A2（iPLA2β）在β细胞中的表达及功能
Can J Physiol Pharmacol. 2004 Oct;82(10):824-32. doi: 10.1139/y04-064.
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Group VIA Ca2+-independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death.组 VIA 钙依赖型磷脂酶 A2（iPLA2β）及其在β细胞程序性细胞死亡中的作用。
Biochimie. 2010 Jun;92(6):627-37. doi: 10.1016/j.biochi.2010.01.005. Epub 2010 Jan 18.
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Amorphous solid dispersion of Berberine mitigates apoptosis via iPLAβ/Cardiolipin/Opa1 pathway in db/db mice and in Palmitate-treated MIN6 β-cells.盐酸小檗碱无定形固体分散体通过 iPLAβ/心磷脂/Opa1 通路减轻 db/db 小鼠和棕榈酸处理的 MIN6β细胞中的细胞凋亡。
Int J Biol Sci. 2019 Jun 2;15(7):1533-1545. doi: 10.7150/ijbs.32020. eCollection 2019.
引用本文的文献
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Differential lipid signaling from CD4 and CD8 T cells contributes to type 1 diabetes development.CD4 和 CD8 T 细胞的差异化脂质信号传导有助于 1 型糖尿病的发展。
Front Immunol. 2024 Sep 18;15:1444639. doi: 10.3389/fimmu.2024.1444639. eCollection 2024.
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Selective Reduction of Ca2+-Independent Phospholipase A2β (iPLA2β)-Derived Lipid Signaling From Macrophages Mitigates Type 1 Diabetes Development.选择性减少巨噬细胞中钙非依赖性磷脂酶 A2β（iPLA2β）衍生的脂质信号转导可减轻 1 型糖尿病的发展。
Diabetes. 2024 Dec 1;73(12):2022-2033. doi: 10.2337/db23-0770.
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Lysophosphatidylserine induces necrosis in pressure overloaded male mouse hearts via G protein coupled receptor 34.溶血磷脂酰丝氨酸通过 G 蛋白偶联受体 34 诱导雄性小鼠心脏在压力超负荷下发生坏死。
Nat Commun. 2023 Jul 31;14(1):4494. doi: 10.1038/s41467-023-40201-4.
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Noncanonical Regulation of cAMP-Dependent Insulin Secretion and Its Implications in Type 2 Diabetes.非规范调节环腺苷酸依赖的胰岛素分泌及其在 2 型糖尿病中的意义。
Compr Physiol. 2023 Jun 26;13(3):5023-5049. doi: 10.1002/cphy.c220031.
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The PNPLA family of enzymes: characterisation and biological role.PNPLA 酶家族：特性与生物学作用。
Arh Hig Rada Toksikol. 2023 Jun 26;74(2):75-89. doi: 10.2478/aiht-2023-74-3723. eCollection 2023 Jun 1.
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Differential Mobilization of the Phospholipid and Triacylglycerol Pools of Arachidonic Acid in Murine Macrophages.花生四烯酸磷脂和三酰甘油池在鼠巨噬细胞中的差异动员。
Biomolecules. 2022 Dec 11;12(12):1851. doi: 10.3390/biom12121851.
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iPLA2β-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment.iPLA2β 基因敲除小鼠经二乙基亚硝胺处理后诱导细胞周期停滞而显示出对肝癌的保护作用。
Int J Mol Sci. 2022 Nov 9;23(22):13760. doi: 10.3390/ijms232213760.
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GPX4-independent ferroptosis-a new strategy in disease's therapy.不依赖谷胱甘肽过氧化物酶4的铁死亡——疾病治疗的新策略。
Cell Death Discov. 2022 Oct 30;8(1):434. doi: 10.1038/s41420-022-01212-0.
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Clinical Characterization and Founder Effect Analysis in Chinese Patients with Phospholipase A2-Associated Neurodegeneration.中国磷脂酶A2相关神经退行性变患者的临床特征及奠基者效应分析
Brain Sci. 2022 Apr 19;12(5):517. doi: 10.3390/brainsci12050517.
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Lipid Droplets, Phospholipase A, Arachidonic Acid, and Atherosclerosis.脂滴、磷脂酶A、花生四烯酸与动脉粥样硬化
Biomedicines. 2021 Dec 13;9(12):1891. doi: 10.3390/biomedicines9121891.
本文引用的文献
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Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to α-Synuclein Gain.磷酸酶 PLA2G6，一个帕金森病相关基因，影响 Vps26 和 Vps35、逆行转运体功能和神经酰胺水平，类似于α-突触核蛋白增益。
Cell Metab. 2018 Oct 2;28(4):605-618.e6. doi: 10.1016/j.cmet.2018.05.019. Epub 2018 Jun 14.
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The structure of iPLAβ reveals dimeric active sites and suggests mechanisms of regulation and localization.iPLAβ的结构揭示了二聚体活性位点，并提示了调节和定位机制。
Nat Commun. 2018 Feb 22;9(1):765. doi: 10.1038/s41467-018-03193-0.
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Mutations in the Drosophila homolog of human PLA2G6 give rise to age-dependent loss of psychomotor activity and neurodegeneration.人类PLA2G6的果蝇同源物中的突变会导致精神运动活动的年龄依赖性丧失和神经退行性变。
Sci Rep. 2018 Feb 13;8(1):2939. doi: 10.1038/s41598-018-21343-8.
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Pla2g6 Deficiency in Zebrafish Leads to Dopaminergic Cell Death, Axonal Degeneration, Increased β-Synuclein Expression, and Defects in Brain Functions and Pathways.Pla2g6 基因敲除导致斑马鱼多巴胺能神经元死亡、轴突变性、β-突触核蛋白表达增加以及脑功能和通路缺陷。
Mol Neurobiol. 2018 Aug;55(8):6734-6754. doi: 10.1007/s12035-017-0846-2. Epub 2018 Jan 17.
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Membrane Allostery and Unique Hydrophobic Sites Promote Enzyme Substrate Specificity.膜变构和独特的疏水区促进酶的底物特异性。
J Am Chem Soc. 2018 Mar 7;140(9):3285-3291. doi: 10.1021/jacs.7b12045. Epub 2018 Feb 26.
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Neurodegeneration with brain iron accumulation.伴脑铁沉积的神经退行性变
Handb Clin Neurol. 2018;147:293-305. doi: 10.1016/B978-0-444-63233-3.00019-1.
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Heart failure-induced activation of phospholipase iPLAγ generates hydroxyeicosatetraenoic acids opening the mitochondrial permeability transition pore.心力衰竭诱导的磷脂酶 iPLAγ 激活产生羟二十碳四烯酸，打开线粒体通透性转换孔。
J Biol Chem. 2018 Jan 5;293(1):115-129. doi: 10.1074/jbc.RA117.000405. Epub 2017 Nov 20.
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PARK14 PLA2G6 mutants are defective in preventing rotenone-induced mitochondrial dysfunction, ROS generation and activation of mitochondrial apoptotic pathway.PARK14 PLA2G6突变体在预防鱼藤酮诱导的线粒体功能障碍、活性氧生成及线粒体凋亡途径激活方面存在缺陷。
Oncotarget. 2017 Sep 15;8(45):79046-79060. doi: 10.18632/oncotarget.20893. eCollection 2017 Oct 3.
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Ageing sensitized by iPLAβ deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acids.iPLAβ 缺陷导致的衰老敏感会引发肝纤维化和肠萎缩，涉及到稳态基因的抑制以及肠道脂质和胆汁酸的改变。
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Dec;1862(12):1520-1533. doi: 10.1016/j.bbalip.2017.09.001. Epub 2017 Sep 6.
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The phospholipase iPLAγ is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling.磷脂酶iPLAγ是从心磷脂释放氧化脂肪链的主要介质，整合线粒体生物能量学和信号传导。
J Biol Chem. 2017 Jun 23;292(25):10672-10684. doi: 10.1074/jbc.M117.783068. Epub 2017 Apr 25.
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