iPLAβ 及其在男性生育力、神经紊乱、代谢紊乱和炎症中的作用。
iPLAβ and its role in male fertility, neurological disorders, metabolic disorders, and inflammation.
机构信息
Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States of America.
Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, United States of America; Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, AL, United States of America.
出版信息
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jun;1864(6):846-860. doi: 10.1016/j.bbalip.2018.10.010. Epub 2018 Nov 5.
Abstract
The Ca-independent phospholipases, designated as group VI iPLAs, also referred to as PNPLAs due to their shared homology with patatin, include the β, γ, δ, ε, ζ, and η forms of the enzyme. The iPLAs are ubiquitously expressed, share a consensus GXSXG catalytic motif, and exhibit organelle/cell-specific localization. Among the iPLAs, iPLAβ has received wide attention as it is recognized to be involved in membrane remodeling, cell proliferation, cell death, and signal transduction. Ongoing studies implicate participation of iPLAβ in a variety of disease processes including cancer, cardiovascular abnormalities, glaucoma, and peridonditis. This review will focus on iPLAβ and its links to male fertility, neurological disorders, metabolic disorders, and inflammation.
摘要
钙非依赖性磷脂酶，被指定为第六组 iPLA，也因其与马铃薯球蛋白的同源性而被称为 PNPLA，包括酶的β、γ、δ、ε、ζ 和 η 形式。iPLA 广泛表达，共享一致的 GXSXG 催化基序，并表现出细胞器/细胞特异性定位。在 iPLA 中，iPLAβ 受到广泛关注，因为它被认为参与膜重塑、细胞增殖、细胞死亡和信号转导。正在进行的研究表明，iPLAβ 参与了多种疾病过程，包括癌症、心血管异常、青光眼和牙周炎。本综述将重点介绍 iPLAβ 及其与男性生育力、神经紊乱、代谢紊乱和炎症的关系。
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