Centre for Biotechnology and Biomedicine, Department of Cell Techniques and Applied Stem Cell Biology, University of Leipzig, Deutscher Platz 5, D-04103 Leipzig, Germany; Department of Plastic Surgery and Hand Surgery, University Hospital Rechts der Isar, Technische Universität München, Munich, Germany.
Department of Plastic Surgery and Hand Surgery, University Hospital Rechts der Isar, Technische Universität München, Munich, Germany.
Drug Discov Today. 2019 Jan;24(1):69-84. doi: 10.1016/j.drudis.2018.10.014. Epub 2018 Nov 5.
Injured human skin fails to regenerate, resulting in scar formation. Annually, 100 million new skin-scarring incidents, occurring as a result of surgery, disease, burns, or sports-related damage, remain untreated. Here, we review knowledge gained from scar-free experimental animal models that have natural regenerative mechanisms for scar-free skin recovery. We also focus on the unique role of endogenous stem cells and other cellular and molecular factors, including the balance of the transforming growth factor-beta (TGF-β) pathway in the context of human skin regeneration. This new strategy opens a new window in drug development for scar-free skin regeneration treatments in both the clinical and cosmetic practice settings.
受伤的人体皮肤无法再生，导致形成疤痕。每年，有 1 亿例新的皮肤疤痕事件发生，这些疤痕是由于手术、疾病、烧伤或与运动相关的损伤造成的，但未得到治疗。在这里，我们回顾了从无疤痕实验动物模型中获得的知识，这些模型具有无疤痕皮肤恢复的天然再生机制。我们还重点介绍了内源性干细胞和其他细胞和分子因素的独特作用，包括转化生长因子-β（TGF-β）通路在人类皮肤再生中的平衡。这种新策略为无疤痕皮肤再生治疗的药物开发开辟了一个新的窗口，无论是在临床还是美容实践环境中。
