Stoica Alexandra Elena, Grumezescu Alexandru Mihai, Hermenean Anca Oana, Andronescu Ecaterina, Vasile Bogdan Stefan
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Gheorghe Polizu Street, 011061 Bucharest, Romania.
National Research Center for Micro and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 060042 Bucharest, Romania.
Nanomaterials (Basel). 2020 Oct 31;10(11):2179. doi: 10.3390/nano10112179.
Every year, millions of people develop scars due to skin injuries after trauma, surgery, or skin burns. From the beginning of wound healing development, scar hyperplasia, and prolonged healing time in wound healing have been severe problems. Based on the difference between adult and fetal wound healing processes, many promising therapies have been developed to decrease scar formation in skin wounds. Currently, there is no good or reliable therapy to cure or prevent scar formation. This work briefly reviews the engineering methods of scarless wound healing, focusing on regenerative biomaterials and different cytokines, growth factors, and extracellular components in regenerative wound healing to minimize skin damage cell types, and scar formation.
每年，数百万人因创伤、手术或皮肤烧伤后的皮肤损伤而形成疤痕。从伤口愈合开始，疤痕增生以及伤口愈合时间延长一直是严重问题。基于成人和胎儿伤口愈合过程的差异，已经开发出许多有前景的疗法来减少皮肤伤口中的疤痕形成。目前，尚无有效或可靠的疗法来治愈或预防疤痕形成。本文简要回顾了无疤痕伤口愈合的工程方法，重点关注再生生物材料以及再生伤口愈合中的不同细胞因子、生长因子和细胞外成分，以尽量减少皮肤损伤细胞类型和疤痕形成。
