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Is it Possible to Successfully Treat Locally Advanced Colon Cancer Using Pre-Operative Chemoradiotherapy?

作者信息

Choi Ji Hun, Kim Jae Hyun, Moon Won, Lee Seung Hun, Baek Sung Uhn, Ahn Byung Kwon, Park Jung Gu, Park Seun Ja

机构信息

Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.

Department of Colorectal Surgery, Kosin University College of Medicine, Busan, Korea.

出版信息

Clin Endosc. 2019 Mar;52(2):191-195. doi: 10.5946/ce.2018.088. Epub 2018 Nov 9.

DOI:10.5946/ce.2018.088
PMID:30408944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6453844/
Abstract

Pre-operative chemoradiotherapy (CRT) is a preferable treatment option for patients with locally advanced rectal cancer. However, few data are available regarding pre-operative CRT for locally advanced colon cancer. Here, we describe two cases of successful treatment with pre-operative CRT and establish evidence supporting this treatment option in patients with locally advanced colon cancer. In the first case, a 65-year-old woman was diagnosed with ascending colon cancer with duodenal invasion. In the second case, a 63-year-old man was diagnosed with a colonic-duodenal fistula due to transverse colon cancer invasion. These case reports will help to establish a treatment consensus for pre-operative CRT in patients with locally advanced colon cancer.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27b/6453844/97454cf055d0/ce-2018-088f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27b/6453844/33c8b40c6069/ce-2018-088f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27b/6453844/2669d9cce4b2/ce-2018-088f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27b/6453844/ecb6320234d1/ce-2018-088f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27b/6453844/97454cf055d0/ce-2018-088f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27b/6453844/33c8b40c6069/ce-2018-088f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27b/6453844/2669d9cce4b2/ce-2018-088f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27b/6453844/ecb6320234d1/ce-2018-088f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27b/6453844/97454cf055d0/ce-2018-088f4.jpg

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本文引用的文献

1
Colorectal Cancer Screening-Who, How, and When?结直肠癌筛查——对象、方法及时机？
Clin Endosc. 2018 Jan;51(1):37-49. doi: 10.5946/ce.2017.141. Epub 2018 Jan 31.
2
Total Neoadjuvant Therapy: A Shifting Paradigm in Locally Advanced Rectal Cancer Management.全新辅助治疗：局部进展期直肠癌治疗模式的转变。
Clin Colorectal Cancer. 2018 Mar;17(1):1-12. doi: 10.1016/j.clcc.2017.06.008. Epub 2017 Jun 27.
3
Neoadjuvant treatment of rectal cancer: where are we now?直肠癌的新辅助治疗：我们目前处于什么阶段？
Gastroenterol Rep (Oxf). 2016 Aug;4(3):206-9. doi: 10.1093/gastro/gow017. Epub 2016 Jul 12.
4
Postoperative adjuvant chemotherapy use in patients with stage II/III rectal cancer treated with neoadjuvant therapy: a national comprehensive cancer network analysis.接受新辅助治疗的 II/III 期直肠癌患者的术后辅助化疗应用：美国国家综合癌症网络分析。
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Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years.局部进展期直肠癌术前与术后放化疗的比较：中位随访 11 年后德国 CAO/ARO/AIO-94 随机 III 期临床试验结果。
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Predictors of multivisceral resection in patients with locally advanced colorectal cancer.局部晚期结直肠癌患者多脏器切除的预测因素
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Preoperative versus postoperative chemoradiotherapy for rectal cancer.直肠癌术前与术后放化疗对比
N Engl J Med. 2004 Oct 21;351(17):1731-40. doi: 10.1056/NEJMoa040694.
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The Mayo Clinic experience with multimodality treatment of locally advanced or recurrent colon cancer.
Ann Surg Oncol. 2002 Mar;9(2):177-85. doi: 10.1007/BF02557371.
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Extended resection for carcinoma of colon and rectum.结肠直肠癌扩大切除术
Surg Clin North Am. 1993 Feb;73(1):117-29. doi: 10.1016/s0039-6109(16)45932-3.
10
Resection for cure of carcinoma of the colon directly invading the duodenum or pancreatic head.为治愈直接侵犯十二指肠或胰头的结肠癌而进行的切除术。
J Am Coll Surg. 1994 Nov;179(5):587-92.