Dipartimento Materno-Infantile, Clinica Ostetrica Ginecologica, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
Dipartimento Materno Infantile, Clinica Ostetrica, ASST Fatebenefratelli Sacco, Ospdeale dei Bambini V. Buzzi, Milan, Italy.
J Matern Fetal Neonatal Med. 2020 Jul;33(13):2137-2141. doi: 10.1080/14767058.2018.1542425. Epub 2019 Jan 8.
This prospective study aims to analyze how CO and NO exposure during pregnancy affects birth and placental weight as well as umbilical arterial pH. The population in study includes 3614 women born in Italy, living in Lombardia Region, consecutively admitted to the Clinica Mangiagalli for an elective cesarean section from January 2004 to December 2006. Outdoor air quality data was provided by the Department of the Regional Environmental Protection Agency and obtained by a network of fixed monitoring stations distributed in eight geographical areas across the region. A positive association was found between birth weight and the concentration of CO to whom women were exposed during the last 10 d of pregnancy (mean change + 28, 95% CI +1 to +55, .04). Conversely, placental weight was not influenced by exposure to CO while a statistically significant weight reduction was related to an increase in NO exposure during the last trimester of pregnancy. Fetal weight was positively associated with an increased exposure to CO during the last 10 d of pregnancy. NO exposure was associated to a placental weight reduction. These findings underline the existence of a complex biological role of such pollutants, especially of CO, in cell oxygenation at a placental level.
本前瞻性研究旨在分析妊娠期间 CO 和 NO 暴露如何影响分娩和胎盘重量以及脐动脉 pH 值。研究人群包括 3614 名在意大利出生、居住在伦巴第大区的女性，她们于 2004 年 1 月至 2006 年 12 月连续在米兰马焦雷临床医院接受选择性剖宫产。室外空气质量数据由区域环境保护局提供，由分布在该地区 8 个地理区域的固定监测站网络获得。研究发现，女性在妊娠最后 10 天接触的 CO 浓度与出生体重呈正相关（平均变化 + 28，95%CI +1 至 +55，.04）。相反，CO 暴露并不影响胎盘重量，而在妊娠最后三个月接触 NO 增加与胎盘重量减轻呈统计学相关。胎儿体重与妊娠最后 10 天 CO 暴露增加呈正相关。NO 暴露与胎盘重量减轻有关。这些发现强调了这些污染物（尤其是 CO）在胎盘水平的细胞氧合中存在复杂的生物学作用。
