Department of Nursing, Pyeongtaek University, Pyeongtaek, Gyeonggi, South Korea.
Department of Preventive Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.
BMC Cancer. 2018 Nov 8;18(1):1081. doi: 10.1186/s12885-018-4960-y.
Utility weight, a measure of health-related quality of life, is used in disease burden measurements and economic evaluations. In this study, we used the visual analogue scale (VAS) and standard gamble (SG) method to determine the utility weights of lung cancer health states in South Korea from a societal perspective.
Six hypothetical health states for lung cancer or a related health state reflective of disease severity were developed: 1) Stage I, 2) Stage II, 3) Stage IIIa, 4) Stage IIIB, 5) Stage IV, and 6) Pulmonary nodule. The description of each health state description was divided into four parts: diagnosis, symptoms, treatment, and progression and prognosis. A total of 515 representative adult Korean participants used a VAS and SG to evaluate these six health states via face-to-face computer-assisted interviews. The means, standard deviations, and median utility weights of the six health states were estimated by valuation method.
The two valuation methods of the scenarios yielded the same mean utility rankings. Pulmonary nodule received the highest rank (VAS, 0.66 and SG, 0.83), whereas Stage 4 was assigned the lowest rank (VAS, 0.09 and SG, 0.31). For all health states, the mean utility weights calculated using the SG were greater than those calculated using the VAS. The differences between the utility weights obtained using the two valuation methods ranged from 0.14 (Stage I) to 0.22 (Stage IV). The two approaches tended to yield larger differences for more severe stages.
This study determined utilities for squamous cell lung cancer that will be useful for estimating the burden of lung cancer and for conducting economic evaluations of lung cancer interventions.
效用权重是衡量健康相关生活质量的一种指标，用于疾病负担测量和经济评估。本研究采用视觉模拟评分法（VAS）和标准赌博法（SG），从社会角度确定韩国肺癌健康状况的效用权重。
我们构建了 6 种肺癌或相关健康状况的假想健康状态，以反映疾病严重程度：1）I 期，2）II 期，3）IIIa 期，4）IIIB 期，5）IV 期，和 6）肺结节。每个健康状态的描述分为四部分：诊断、症状、治疗和进展与预后。共有 515 名代表性的韩国成年参与者通过面对面的计算机辅助访谈，使用 VAS 和 SG 对这 6 种健康状态进行评估。通过估值法对 6 种健康状态的均值、标准差和中位数效用权重进行估计。
两种估值方法得出的情景均值效用排名相同。肺结节的排名最高（VAS，0.66；SG，0.83），而 4 期的排名最低（VAS，0.09；SG，0.31）。对于所有健康状态，使用 SG 计算得出的平均效用权重均大于使用 VAS 计算得出的权重。两种估值方法得出的效用权重之间的差异范围为 0.14（I 期）至 0.22（IV 期）。两种方法在评估更严重的阶段时往往会产生更大的差异。
本研究确定了鳞状细胞肺癌的效用，这将有助于估计肺癌负担，并对肺癌干预措施进行经济评估。
