埃塞俄比亚东南部巴勒州戈巴和锡纳纳县尿路感染孕妇的细菌谱、抗生素敏感性模式及相关因素

Bacterial profile, antibiotic susceptibility pattern and associated factors among pregnant women with Urinary Tract Infection in Goba and Sinana Woredas, Bale Zone, Southeast Ethiopia.

作者信息

Taye Solomon, Getachew Motuma, Desalegn Zelalem, Biratu Abera, Mubashir Khan

机构信息

Microbiology, Immunology and Parasitology Department, College of Medicine and Health Sciences, Wachemo University, P.O. Box 667, Hossana, Ethiopia.

College of Medicine and Health Sciences, Wollega University, P.O. Box 395, Nekemte, Ethiopia.

出版信息

BMC Res Notes. 2018 Nov 8;11(1):799. doi: 10.1186/s13104-018-3910-8.

DOI:10.1186/s13104-018-3910-8

PMID:30409206

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6225670/

Abstract

OBJECTIVE

Urinary tract infection (UTI) is one of the commonest infections affecting millions worldwide, especially pregnant women. It can lead to poor maternal and perinatal outcomes. Untreated UTI can be associated with serious obstetric complications. So the objective of present study was to determine the bacterial profile, antibiotic susceptibility pattern and associated factors of UTI among pregnant women in Goba and Sinana Woredas, Bale Zone, Southeast Ethiopia.

RESULTS

The overall prevalence of UTI was 44/169 (26%) with 18/51 (35.3%) in symptomatic and 26/118 (22%) in asymptomatic pregnant women, respectively. Of the 44 bacterial isolates, E. coli 12/44 (27.3%), K. pneumonia 9/44 (20.5%) and S. marcescens 4/44 (9.1%) were the commonest bacterial pathogens. C. freundii 3/44 (6.8%), M. morganii 3/44 (6.8%), P. aeruginosa 3/44 (6.8%) and S. enteritidis 3/44 (6.8%) isolates were the moderately identified bacterial species. K. oxytoca 1/44 (2.3%) was the least common bacterium to be detected. The antibiotic susceptibility pattern showed that 90.9%, 88.6% and 86.3% of the isolates were sensitive to amoxicillin/clavulanic acid, gentamycin and norfloxacin, respectively. Significant bacteriuria was associated with low educational status (p = 0.024; AOR = 6.617; CI = 1.87-9.94) and kidney problems (p = 0.018; AOR = 0.286; CI = 1.19-2.81).

摘要

目的

尿路感染（UTI）是影响全球数百万人的最常见感染之一，尤其是孕妇。它可导致孕产妇和围产期不良结局。未经治疗的尿路感染可能与严重的产科并发症相关。因此，本研究的目的是确定埃塞俄比亚东南部巴勒州戈巴和锡纳纳县孕妇尿路感染的细菌谱、抗生素敏感性模式及相关因素。

结果

尿路感染的总体患病率为44/169（26%），有症状孕妇中为18/51（35.3%），无症状孕妇中为26/118（22%）。在44株细菌分离物中，大肠埃希菌12/44（27.3%）、肺炎克雷伯菌9/44（20.5%）和粘质沙雷氏菌4/44（9.1%）是最常见的细菌病原体。弗氏柠檬酸杆菌3/44（6.8%）、摩根摩根菌3/44（6.8%）、铜绿假单胞菌3/44（6.8%）和肠炎沙门氏菌3/44（6.8%）分离物是中等鉴定出的细菌种类。产酸克雷伯菌1/44（2.3%）是检测到的最不常见细菌。抗生素敏感性模式显示，分别有90.9%、88.6%和86.3%的分离物对阿莫西林/克拉维酸、庆大霉素和诺氟沙星敏感。显著菌尿与低教育水平（p = 0.024；比值比 = 6.617；可信区间 = 1.87 - 9.94）和肾脏问题（p = 0.018；比值比 = 0.286；可信区间 = 1.19 - 2.81）相关。