University of Colorado Denver.
University of Utah.
Blood. 2018 Nov 8;132(19):2007-2008. doi: 10.1182/blood-2018-09-872101.
The concept of race based on physical appearance, social grouping, or self-identification has been challenged for decades. With the recent sequencing of thousands of human genomes, this concept has been further redefined. In this issue of , Heenkenda et al show that the A allele frequency of the rs773902 A/G dimorphism associated with increased platelet reactivity is significantly lower in Somalians than what has been previously described for blacks in the United States, underscoring the importance of genetics and geographic ancestry for determining disease risk.
种族的概念基于外貌、社会群体或自我认同，几十年来一直受到挑战。随着最近数千个人类基因组的测序，这一概念得到了进一步的重新定义。在本期 杂志中，Heenkenda 等人表明，与血小板反应性增加相关的 rs773902 A/G 二态性的 A 等位基因频率在索马里人中明显低于以前在美国黑人中描述的频率，这强调了遗传和地理祖籍对确定疾病风险的重要性。
