Department of Dermatology, Rambam Medical Center, Haifa, Israel.
The Rappaport Faculty of Medicine, Technion, Haifa, Israel.
Australas J Dermatol. 2019 May;60(2):e109-e112. doi: 10.1111/ajd.12948. Epub 2018 Nov 8.
BACKGROUND/OBJECTIVES: Erosive oral lichen planus (LP) may be painful and debilitating. Symptomatic oral LP has been treated with a wide spectrum of topical and systemic therapies, but few have been evaluated in large series. Hydroxychloroquine is suggested to be effective in oral LP.
Twenty-one consecutive patients with erosive, biopsy-confirmed oral LP were prescribed. hydroxychloroquine sulphate 400 mg/day. Symptomatic improvement was evaluated by means of a visual analogue scale into three groups: no change, moderate to marked improvement and complete remission.
Five (24%) patients obtained complete remission, 12 (57%) patients showed moderate to marked improvement, 3 (14%) patients did not improve at all and in one patient therapy was terminated after 1 month due to side effects. Response to therapy was observed after 2-4 months. Side effects which ultimately led to termination of therapy in three patients were elevated creatinine serum levels (after 1 month), visual field defects (after 8 months) and hyperpigmentation (after 24 months). Among six patients who responded to therapy, three flared on stopping.
Hydroxychloroquine sulphate may be effective and relatively safe treatment for erosive oral LP.
背景/目的：糜烂型口腔扁平苔藓（LP）可能会引起疼痛和身体不适。有多种局部和全身疗法被用于治疗有症状的口腔 LP，但很少有大样本的研究对其进行评估。羟氯喹被认为对口腔 LP 有效。
21 例糜烂型、经活检证实的口腔 LP 患者接受硫酸羟氯喹 400 mg/天的治疗。通过视觉模拟评分将症状改善情况分为三组：无变化、中度至明显改善和完全缓解。
5 例（24%）患者完全缓解，12 例（57%）患者中度至明显改善，3 例（14%）患者无改善，1 例患者因副作用在 1 个月后停药。治疗反应在 2-4 个月观察到。最终导致 3 例患者停药的副作用分别为血清肌酐升高（1 个月后）、视野缺损（8 个月后）和色素沉着过度（24 个月后）。在对治疗有反应的 6 例患者中，有 3 例在停药后复发。
硫酸羟氯喹可能是治疗糜烂型口腔 LP 的有效且相对安全的方法。
