硫酸羟氯喹（羟氯喹啉）改善口腔扁平苔藓：一项开放性试验。
Hydroxychloroquine sulfate (Plaquenil) improves oral lichen planus: An open trial.
作者信息
Eisen D
机构信息
Dermatology Associates of Cincinnati, Inc., OH 45230.
出版信息
J Am Acad Dermatol. 1993 Apr;28(4):609-12. doi: 10.1016/0190-9622(93)70082-5.
BACKGROUND
Oral lichen planus is chronic and can be debilitating. Topical corticosteroids are most frequently used for treatment, but they are not always effective.
OBJECTIVE
Hydroxychloroquine sulfate (Plaquenil), an antimalarial agent, was evaluated in an open trial (10 patients) for its ability to improve oral lichen planus.
METHODS
Patients received hydroxychloroquine, 200 to 400 mg daily, as a monotherapy for 6 months. Patients were assessed at baseline and every 4 to 8 weeks during treatment. Baseline ophthalmologic examinations were performed, and laboratory values were monitored before and during treatment.
RESULTS
Nine of ten patients had an excellent response to therapy. Three of six patients with erosions at baseline had complete healing. Pain relief and reduced erythema were usually observed after 1 to 2 months of therapy, but erosions required 3 to 6 months of treatment before they resolved. There were no adverse effects.
CONCLUSION
Hydroxychloroquine may be useful in the treatment of oral lichen planus.
背景
口腔扁平苔藓是一种慢性疾病，可能使人虚弱。局部用皮质类固醇是最常用的治疗方法，但并非总是有效。
目的
在一项开放试验（10例患者）中评估抗疟药硫酸羟氯喹（羟氯喹）改善口腔扁平苔藓的能力。
方法
患者接受羟氯喹，每日200至400毫克，作为单一疗法治疗6个月。在基线时以及治疗期间每4至8周对患者进行评估。进行了基线眼科检查，并在治疗前和治疗期间监测实验室值。
结果
10例患者中有9例对治疗反应良好。6例基线时有糜烂的患者中有3例完全愈合。治疗1至2个月后通常观察到疼痛缓解和红斑减轻，但糜烂需要3至6个月的治疗才能消退。未出现不良反应。
结论
羟氯喹可能对口腔扁平苔藓的治疗有用。
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