Karteszi M, Van de Kar L D, Makara G B, Stark E, Ganong W F
Neuroendocrinology. 1982;34(5):323-6. doi: 10.1159/000123321.
The effect of the serotonin-releasing drug parachloroamphetamine (PCA) on plasma renin activity was studied in rats 4 days after surgical lesions of the mediobasal hypothalamus, anterolateral deafferentation of the mediobasal hypothalamus, posterolateral deafferentation, or hypophysectomy. PCA increased plasma renin activity in sham-operated rats, but it failed to increase plasma renin activity in rats with mediobasal hypothalamic lesions or posterolateral deafferentation. The response to PCA was unaffected by anterolateral deafferentation and enhanced by hypophysectomy. There were no significant differences in plasma renin activity in lesioned, deafferented, and hypophysectomized rats injected with saline. The data indicate that the mediobasal hypothalamus is part of the pathway by which central serotonergic neurons affect renin secretion, and that the effect is not mediated via hormones of the pituitary gland.
在大鼠中，研究了5-羟色胺释放药物对氯苯丙胺（PCA）对血浆肾素活性的影响，这些大鼠在进行了下丘脑内侧基底部手术损伤、下丘脑内侧基底部前外侧去传入、后外侧去传入或垂体切除术后4天。PCA可增加假手术大鼠的血浆肾素活性，但不能增加下丘脑内侧基底部损伤或后外侧去传入大鼠的血浆肾素活性。对PCA的反应不受前外侧去传入的影响，但垂体切除可增强该反应。注射生理盐水的损伤、去传入和垂体切除大鼠的血浆肾素活性无显著差异。数据表明，下丘脑内侧基底部是中枢5-羟色胺能神经元影响肾素分泌的途径的一部分，且该作用不是通过垂体激素介导的。
