Drobisz Dominik, Damborská Alena
Department of Psychiatry, University Hospital and Masaryk University, Brno, Czech Republic.
Department of Psychiatry, University Hospital and Masaryk University, Brno, Czech Republic; Department of Basic Neurosciences, University of Geneva, Campus Biotech, Geneva, Switzerland; CEITEC - Central European Institute of Technology, Brain and Mind Research Program, Masaryk University, Brno, Czech Republic.
Behav Brain Res. 2019 Feb 1;359:266-273. doi: 10.1016/j.bbr.2018.11.004. Epub 2018 Nov 8.
Deep brain stimulation (DBS) is a new therapeutic approach for treatment-resistant depression (TRD). There is a preliminary evidence of the efficacy and safety of DBS for TRD in the subgenual anterior cingulate cortex, the ventral capsule/ventral striatum, the nucleus accumbens, the lateral habenula, the inferior thalamic peduncle, the medial forebrain bundle, and the bed nucleus of the stria terminalis. Optimal stimulation targets, however, have not yet been determined. Here we provide updated knowledge substantiating the suitability of each of the current and potential future DBS targets for treating depression. In this review, we discuss the future outlook for DBS treatment of depression in light of the fact that antidepressant effects of DBS can be achieved using different targets.
深部脑刺激（DBS）是一种针对难治性抑郁症（TRD）的新型治疗方法。有初步证据表明，DBS用于治疗膝下前扣带回皮质、腹侧囊/腹侧纹状体、伏隔核、外侧缰核、丘脑下脚、内侧前脑束和终纹床核的TRD具有疗效和安全性。然而，最佳刺激靶点尚未确定。在此，我们提供最新知识，以证实当前及未来潜在的每个DBS靶点治疗抑郁症的适用性。在本综述中，鉴于使用不同靶点均可实现DBS的抗抑郁作用，我们讨论了DBS治疗抑郁症的未来前景。
