Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, PR China; Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center, 430071 Wuhan, Hubei, PR China.
Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, PR China.
Gene. 2019 Feb 15;685:202-210. doi: 10.1016/j.gene.2018.11.022. Epub 2018 Nov 9.
Despite advances in early diagnosis and treatment, cancer still remains the major reason of mortality worldwide. The forkhead box A (FOXA) family is reported to participate in diverse human diseases. However, little is known about their expression and prognostic values in human lung cancer. Herein, we conducted a detailed cancer vs. normal analysis. The mRNA expression levels of FOXA family in numerous kind of cancers, including lung cancer, were analyzed using the Oncomine and GEPIA database. We observed that the mRNA expression levels of FOXA1, and FOXA3 were all increased while FOXA2 were decreased in most cancers compared with normal tissues, especially in lung cancer. Moreover, the expression levels of FOXA1, and FOXA3 are also highly expressed, while FOXA2 were decreased in almost all cancer cell lines, particularly in lung cancer cell lines, analyzing by Cancer Cell Line Encyclopedia (CCLE) and EMBL-EBI databases. Furthermore, the LinkedOmics database was used to evaluate the prognostic values, indicating that higher expression of FOXA1, FOXA3 indicated a poor overall survival (OS), while increased FOXA2 revealed a better OS in lung cancer. To conclusion, FOXA family showed significant expression differences between cancer and normal tissues, especially lung cancer, and FOXA1, FOXA3 could be promising prognostic biomarkers for lung cancer.
尽管在早期诊断和治疗方面取得了进展，但癌症仍然是全球主要的死亡原因。叉头框 A（FOXA）家族被报道参与多种人类疾病。然而，它们在人类肺癌中的表达和预后价值知之甚少。在此，我们进行了详细的癌症与正常组织分析。使用 Oncomine 和 GEPIA 数据库分析了 FOXA 家族在包括肺癌在内的多种癌症中的 mRNA 表达水平。我们观察到，与正常组织相比，FOXA1 和 FOXA3 的 mRNA 表达水平在大多数癌症中均升高，而 FOXA2 则降低，尤其是在肺癌中。此外，通过 Cancer Cell Line Encyclopedia (CCLE) 和 EMBL-EBI 数据库分析，FOXA1 和 FOXA3 的表达水平也高度表达，而 FOXA2 在几乎所有癌细胞系中均降低，尤其是在肺癌细胞系中。此外，使用 LinkedOmics 数据库评估了预后价值，表明 FOXA1 和 FOXA3 的高表达预示着肺癌的总体生存率（OS）较差，而 FOXA2 的增加则预示着肺癌的 OS 较好。总之，FOXA 家族在癌症与正常组织之间表现出显著的表达差异，尤其是在肺癌中，FOXA1 和 FOXA3 可能是肺癌有前途的预后生物标志物。
