Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
Clin Neurophysiol. 2018 Dec;129(12):2577-2585. doi: 10.1016/j.clinph.2018.09.028. Epub 2018 Oct 30.
Greater relative right- than left-frontal cortical activity has been frequently found in adults with major depression (MD). As the few studies in adolescents with MD have been inconclusive, the aim of this study was to assess frontal alpha asymmetry (FAA) in an adolescent sample with MD whilst taking into account possible confounding variables such as disease state and comorbid anxiety disorder.
An 8-minute resting frontal EEG was assessed in 34 healthy controls (HCs), 16 adolescents with MD in remission without comorbid anxiety disorder (rMDa-), 22 adolescents with acute depression without comorbid anxiety disorder (MDa-), and 23 adolescents with acute depression and comorbid anxiety disorder (MDa+). Alpha power was analyzed over corresponding frontal Regions of Interests.
Compared to HCs, MDa+ adolescents demonstrated more left- than right-sided EEG alpha power, indicating greater right-than left-frontal cortical activity. No other group differences emerged.
The results suggest that greater relative right-frontal cortical activity in adolescent MD is not a result of disease state but can be attributed to comorbid anxiety disorder.
Results suggest that FAA is not linked to adolescent depression per se and highlight the importance of considering comorbid disorders when examining asymmetry patterns in adolescent MD.
与健康对照者（HCs）相比，患有重性抑郁症（MD）的成年人常表现出更强的右侧额皮质活动。由于几项青少年 MD 研究尚无定论，因此本研究旨在评估 MD 缓解期且无共病焦虑障碍的青少年样本的额α不对称性（FAA），同时考虑到可能的混杂变量，如疾病状态和共病焦虑障碍。
对 34 名健康对照者（HCs）、16 名 MD 缓解期且无共病焦虑障碍的青少年（rMDa-）、22 名急性 MD 且无共病焦虑障碍的青少年（MDa-）和 23 名急性 MD 且共病焦虑障碍的青少年（MDa+）进行了 8 分钟的静息额 EEG 评估。在相应的额 ROI 上分析了α功率。
与 HCs 相比，MDa+青少年表现出更强的左侧而非右侧 EEGα功率，表明右侧额皮质活动强于左侧。未出现其他组间差异。
结果表明，青少年 MD 中相对较强的右侧额皮质活动不是疾病状态的结果，而是可以归因于共病焦虑障碍。
结果表明，FAA 与青少年抑郁症本身无关，并强调在检查青少年 MD 中的不对称模式时考虑共病障碍的重要性。
