Luo Yiwen, Tang Mingcong, Fan Xiwang
Clinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai, 200124, China.
Npj Ment Health Res. 2025 Jan 17;4(1):2. doi: 10.1038/s44184-025-00117-x.
This meta-analysis investigated resting frontal alpha asymmetry (FAA) as a potential biomarker for major depressive disorder (MDD). Studies included articles utilizing FAA measure involving EEG electrodes (F3/F4, F7/F8, or Fp1/Fp2) and covering both MDD and controls. Hedges' d was calculated from FAA means and standard deviations (SDs). A systematic search of PubMed through July 2023 identified 23 studies involving 1928 MDD participants and 2604 controls. The analysis revealed a small but significant grand mean effect size (ES) for FAA (F4 - F3), suggesting limited diagnostic value of FAA in MDD. Despite the presence of high heterogeneity across studies, subgroup analyses did not identify significant differences based on calculation formula, reference montage, age, or depression severity. The findings indicate that FAA may have limited standalone diagnostic utility but could complement existing clinical assessments for MDD, highlighting the need for a multifaceted approach to depression diagnosis and prognosis.
这项荟萃分析研究了静息额叶α不对称性（FAA）作为重度抑郁症（MDD）潜在生物标志物的情况。纳入的研究文章采用了涉及脑电图电极（F3/F4、F7/F8或Fp1/Fp2）的FAA测量方法，涵盖了MDD患者和对照。Hedges' d是根据FAA均值和标准差（SD）计算得出的。通过对截至2023年7月的PubMed进行系统检索，确定了23项研究，涉及1928名MDD参与者和2604名对照。分析显示，FAA（F4 - F3）存在虽小但显著的总体平均效应量（ES），这表明FAA在MDD中的诊断价值有限。尽管各研究之间存在高度异质性，但亚组分析未发现基于计算公式、参考导联、年龄或抑郁严重程度的显著差异。研究结果表明，FAA的独立诊断效用可能有限，但可补充MDD现有的临床评估，凸显了采用多方面方法进行抑郁症诊断和预后判断的必要性。
