Russo Chiara, Giannotti Chiara, Signori Alessio, Cea Michele, Murialdo Roberto, Ballestrero Alberto, Scabini Stefano, Romairone Emanuele, Odetti Patrizio, Nencioni Alessio, Monacelli Fiammetta
Department of Internal Medicine and Medical Specialties (DIMI), Section of Geriatrics, Genoa, Italy.
DISSAL, Section of Biostatistics, Department of Health Sciences, University of Genova, Genoa, Italy.
Oncotarget. 2018 Oct 12;9(80):35056-35068. doi: 10.18632/oncotarget.26147.
Comprehensive Geriatric Assessment (CGA), the gold standard for detecting frailty in elderly cancer patients, is time-consuming and hard to apply in routine clinical practice. Here we compared the performance of two screening tools for frailty, G8 and SAOP2 for their accuracy in identifying vulnerable patients.
We tested G8 and SAOP2 in 282 patients aged 65 or older with a diagnosis of solid cancer and candidate to undergo surgical, medical and/or radiotherapy treatment. CGA, including functional and cognitive status, depression, nutrition, comorbidity, social status and quality of life was used as reference. ROC curves were used to compare two screening tools.
Mean patient age was 79 years and 54% were female. Colorectal and breast cancer were the most common types cancer (49% and 24%). Impaired CGA, G8, and SAOP2 were found in 62%, 89%, and 94% of the patients, respectively. SAOP2 had a better sensitivity (AUC 0.85, p<0.032) than G8 (AUC 0.79), with higher performance in breast cancer patients (AUC 0.93) and in patients aged 70-80 years (AUC 0.87).
G8 and SAOP2 both showed good screening capacity for frailty in the cancer patient population we examined with SAOP2 showing a slightly better performance than G8.
综合老年评估（CGA）是检测老年癌症患者虚弱状态的金标准，但耗时且难以应用于常规临床实践。在此，我们比较了两种虚弱筛查工具G8和SAOP2在识别脆弱患者方面的准确性。
我们在282例65岁及以上诊断为实体癌且拟接受手术、药物和/或放射治疗的患者中测试了G8和SAOP2。以包括功能和认知状态、抑郁、营养、合并症、社会状况和生活质量的CGA作为参照。采用ROC曲线比较两种筛查工具。
患者平均年龄为79岁，54%为女性。结直肠癌和乳腺癌是最常见的癌症类型（分别为49%和24%）。分别有62%、89%和94%的患者CGA、G8和SAOP2受损。SAOP2的敏感性（AUC 0.85，p<0.032）优于G8（AUC 0.79），在乳腺癌患者（AUC 0.93）和70 - 80岁患者（AUC 0.87）中表现更佳。
在我们所研究的癌症患者群体中，G8和SAOP2对虚弱均显示出良好的筛查能力，其中SAOP2的表现略优于G8。
