Shi Mingyu, Ma Liwei, Zhang Jinsong, Yan Qichang
Department of Ophthalmology, The Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, The Key Laboratory of Lens in Liaoning Province, Shenyang, 110005 Liaoning, China.
J Ophthalmol. 2018 Oct 17;2018:3760280. doi: 10.1155/2018/3760280. eCollection 2018.
The purpose of this observational case series study was to investigate the role of 25 MHz ultrasound biomicroscopy (UBM) in detecting subluxated lenses and compare it with 50 MHz UBM.
45 patients (49 eyes) with suspected subluxation of the lens and 20 normal volunteers (40 eyes) were included. Different cross-sectional images of the lens position were captured in axial and longitudinal scanning modes using 25 and 50 MHz UBM. The main outcome measurements included the linear distance between the lens equator and ciliary process, the difference value (D-value) between the same cross section of the above bilateral linear distance in the normal and the subluxated subjects, the diagnostic accuracy, and the testing times obtained with 25 and 50 MHz UBM.
The position of the lens on axial sections could be clearly shown by using 25 MHz UBM. The D-value of the subluxated eyes was 1-2 mm longer than that of the normal ones. There was a statistically significant difference between 25 and 50 MHz UBM in showing subluxation of the lens, the testing time was significantly faster (2.0 min versus 7.5 min), and the diagnostic accuracy was much higher (98.0% versus 71.4%) with 25 versus 50 MHz UBM. Fifteen eyes with slightly subluxated lens were detected by 25 MHz UBM, and only one eye with slight lens subluxation was detected by 50 MHz UBM.
The results indicated that 25 MHz UBM has a greater diagnostic value than 50 MHz UBM in verifying the status of the lens subluxation and can provide reliable and quantitative imaging evidence for clinical use. This trial is registered with ChiCTR-DOD -15007603.
本观察性病例系列研究旨在探讨25兆赫超声生物显微镜（UBM）在检测晶状体半脱位中的作用，并将其与50兆赫UBM进行比较。
纳入45例（49只眼）疑似晶状体半脱位患者和20名正常志愿者（40只眼）。使用25兆赫和50兆赫UBM在轴向和纵向扫描模式下采集晶状体位置的不同横截面图像。主要观察指标包括晶状体赤道与睫状体之间的线性距离、正常和半脱位受试者上述双侧线性距离同一横截面的差值（D值）、诊断准确性以及使用25兆赫和50兆赫UBM获得的检查时间。
使用25兆赫UBM可清晰显示晶状体在轴位切片上的位置。半脱位眼的D值比正常眼长1 - 2毫米。25兆赫和50兆赫UBM在显示晶状体半脱位方面存在统计学显著差异，25兆赫UBM的检查时间明显更快（2.0分钟对7.5分钟），诊断准确性更高（98.0%对71.4%）。25兆赫UBM检测出15只晶状体轻度半脱位的眼，而50兆赫UBM仅检测出一只晶状体轻度半脱位的眼。
结果表明，在验证晶状体半脱位状态方面，25兆赫UBM比50兆赫UBM具有更大的诊断价值，可为临床应用提供可靠的定量成像证据。本试验在中国临床试验注册中心注册号为ChiCTR - DOD - 15007603。
