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酷似喉癌的孤立性喉淀粉样变

Isolated Laryngeal Amyloidosis Mimicking Laryngeal Cancer.

作者信息

Muneeb Aeman, Gupta Supriya

机构信息

Radiology, Aga Khan University, Karachi, PAK.

Radiology, Rush University Medical Center, Chicago , USA.

出版信息

Cureus. 2018 Aug 6;10(8):e3106. doi: 10.7759/cureus.3106.

DOI:10.7759/cureus.3106
PMID:30416894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6223666/
Abstract

Amyloidosis is the deposition of an extracellular fibrillar protein in the tissues leading to organ dysfunction. Laryngeal amyloidosis is a rare phenomenon. We report a case of isolated laryngeal amyloidosis which was initially suspicious for laryngeal cancer on magnetic resonance imaging (MRI) but histopathology showed the presence of amyloid. Systemic workup was negative. The patient is being managed conservatively.

摘要

淀粉样变性是一种细胞外纤维状蛋白在组织中沉积导致器官功能障碍的疾病。喉淀粉样变性是一种罕见现象。我们报告一例孤立性喉淀粉样变性病例,该病例最初在磁共振成像(MRI)上疑似喉癌,但组织病理学显示存在淀粉样蛋白。全身检查结果为阴性。该患者正在接受保守治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b8e/6223666/550b55a2c2c4/cureus-0010-00000003106-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b8e/6223666/273400ed00e7/cureus-0010-00000003106-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b8e/6223666/550b55a2c2c4/cureus-0010-00000003106-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b8e/6223666/273400ed00e7/cureus-0010-00000003106-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b8e/6223666/550b55a2c2c4/cureus-0010-00000003106-i02.jpg

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本文引用的文献

1
New and developing therapies for AL amyloidosis.治疗AL淀粉样变性的新型及正在研发的疗法。
Expert Opin Pharmacother. 2017 Feb;18(2):139-149. doi: 10.1080/14656566.2016.1274971. Epub 2016 Dec 29.
2
The Prevalence and Management of Systemic Amyloidosis in Western Countries.西方国家系统性淀粉样变性的患病率和管理。
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Laryngo-tracheobronchial amyloidosis: a case report and review of literature.喉气管支气管淀粉样变性:一例病例报告及文献复习
Int J Clin Exp Pathol. 2014 Sep 15;7(10):7088-93. eCollection 2014.
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Isolated laryngeal amyloidosis.孤立性喉淀粉样变性
Iran J Otorhinolaryngol. 2013 Winter;25(70):49-52.
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Pathophysiology and treatment of systemic amyloidosis.系统性淀粉样变性的病理生理学和治疗。
Nat Rev Nephrol. 2013 Oct;9(10):574-86. doi: 10.1038/nrneph.2013.171. Epub 2013 Aug 27.
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Laryngeal amyloidosis.喉淀粉样变性
J Otolaryngol. 2005 Feb;34(1):60-3. doi: 10.2310/7070.2005.03131.
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Amyloidosis of the larynx: a clinicopathologic study of 11 cases.喉淀粉样变性:11例临床病理研究
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