Department of Psychiatry, Neurology, Psychosomatics, Psychotherapy in Childhood and Adolescence, University Medical Center of Rostock, Rostock, Germany.
Brain Behav. 2018 Dec;8(12):e01155. doi: 10.1002/brb3.1155. Epub 2018 Nov 12.
This study investigated simultaneously the impact of methylphenidate (MPH) on the interaction of inhibitory and facilitative pathways in regions processing motor and cognitive functions.
Neural markers of attention and response control (event-related potentials) and motor cortical excitability (transcranial magnetic stimulation) and their pharmacological modulation by MPH were measured simultaneously in a sample of healthy adults (n = 31) performing a cued choice reaction test.
Methylphenidate modulated attentional gating and response preparation processes (increased contingent negative variation) and response inhibition (increased nogo P3). N1, cue- and go-P3 were not affected by MPH. Motor cortex facilitation, measured with long-interval cortical facilitation, was increased under MPH in the nogo condition and was positively correlated with the P3 amplitude.
Methylphenidate seems particularly to enhance response preparation processes. The MPH-induced increased motor cortex facilitation during inhibitory task demands was accompanied by increased terminal response inhibition control, probably as a compensatory process.
本研究同时考察了哌醋甲酯（MPH）对处理运动和认知功能的区域中抑制和促进途径相互作用的影响。
在一组健康成年人（n=31）中同时测量了注意和反应控制（事件相关电位）的神经标记物以及运动皮质兴奋性（经颅磁刺激）及其被 MPH 的药物调节情况，这些成年人在执行提示选择反应测试。
MPH 调节了注意门控和反应准备过程（增加了伴随负变）和反应抑制（增加了 nogo P3）。MPH 对 N1、线索和 go-P3 没有影响。用长间隔皮质易化测量的运动皮质易化在 nogo 条件下 MPH 下增加，与 P3 幅度呈正相关。
MPH 似乎特别增强了反应准备过程。在抑制任务需求期间，MPH 诱导的运动皮质易化增加伴随着终端反应抑制控制的增加，这可能是一种代偿过程。
