Barnes P J
Cardiothoracic Institute, Brompton Hospital, London, United Kingdom.
Am J Med. 1988 Jul 29;85(1B):64-70. doi: 10.1016/0002-9343(88)90245-8.
The results of recent research strongly suggest that airway inflammation, which may increase at night as a result of circadian troughs in blood epinephrine and cortisol concentrations, underlies the bronchial hyperresponsiveness that is almost certainly a major contributor to the pathogenesis of nocturnal asthma. This article reviews what is known about the nature and complex interactions of the inflammatory cells and mediators that may be involved in asthma, with particular emphasis on nocturnal asthma. The roles of platelet-activating factor antagonists, corticosteroids, and theophylline in suppressing this response also are discussed.
近期研究结果有力地表明，气道炎症可能因血液中肾上腺素和皮质醇浓度的昼夜波动在夜间加剧，它是支气管高反应性的基础，而支气管高反应性几乎肯定是夜间哮喘发病机制的主要促成因素。本文综述了关于可能参与哮喘的炎症细胞和介质的性质及复杂相互作用的已知情况，尤其着重于夜间哮喘。还讨论了血小板活化因子拮抗剂、皮质类固醇和茶碱在抑制这种反应中的作用。
