Pratap Kemant, Kumar Atul
Medicinal and Process Chemistry Division , CSIR-Central Drug Research Institute , Sector 10, Jankipuram Extension , Lucknow - 226031 , India.
Academy of Scientific & Innovative Research (AcSIR) , New Delhi , India.
Org Lett. 2018 Dec 7;20(23):7451-7454. doi: 10.1021/acs.orglett.8b03196. Epub 2018 Nov 12.
The first intermolecular dehydrogenative carboamination of alkenes with aromatic amines and N-substituted isatin has been developed using palladium as a catalyst. This multicomponent reaction is a valuable synthetic tool for difunctionalization of the alkene with retention of the C-C double bond. This reaction has two very distinguishing features: (1) the formation of the C-N and C-C bonds with retention of the double bond and (2) high regioselectivity. Thus, this strategy has opened up a new area in chemistry.
利用钯作为催化剂，首次实现了烯烃与芳香胺和N-取代靛红之间的分子间脱氢碳胺化反应。这种多组分反应是一种有价值的合成工具，可用于在保留碳-碳双键的情况下对烯烃进行双官能化。该反应有两个非常显著的特点：（1）在保留双键的情况下形成碳-氮键和碳-碳键；（2）具有高区域选择性。因此，这一策略在化学领域开辟了一个新的方向。
