Eusebi V, Ceccarelli C, Daniele E, Collina G, Viale G, Mancini A M
Institute of Anatomical Pathology, University of Bologna, Italy.
Appl Pathol. 1988;6(3):197-207.
Two cases of 'adult' rhabdomyoma and 2 of 'fetal' rhabdomyoma have been immunologically studied using several antisera specific of skeletal muscle fibers proteins. This paper also deals with a review of the literature on these rare benign skeletal muscle proliferations. It is concluded that 'adult' rhabdomyoma contains fetal myosin and therefore the term 'adult' does not seem immunologically appropriate any longer. In addition the tumoral cells show the same level of differentiation as seen in neonatal skeletal muscle. Therefore it seems that the definition of neonatal rhabdomyoma is more appropriate for these benign muscular proliferations. The 2 cases of fetal rhabdomyoma appear phenotypically similar to normally developing myoblasts and contain fetal myosin. Therefore it seems that the definition 'fetal' is here appropriate for what appears to be a disorganized proliferation of otherwise normal fetal skeletal muscle fibers. The differential diagnosis between these latter tumors and rhabdomyosarcomas has been discussed.
使用几种针对骨骼肌纤维蛋白的特异性抗血清，对两例“成人型”横纹肌瘤和两例“胎儿型”横纹肌瘤进行了免疫研究。本文还对这些罕见的良性骨骼肌增生的文献进行了综述。得出的结论是，“成人型”横纹肌瘤含有胎儿肌球蛋白，因此“成人型”这一术语在免疫学上似乎不再合适。此外，肿瘤细胞显示出与新生儿骨骼肌相同程度的分化。因此，新生儿横纹肌瘤的定义似乎更适合这些良性肌肉增生。两例胎儿型横纹肌瘤在表型上与正常发育的成肌细胞相似，并含有胎儿肌球蛋白。因此，“胎儿型”这一定义似乎适用于看似正常胎儿骨骼肌纤维无序增生的情况。本文还讨论了后一种肿瘤与横纹肌肉瘤之间的鉴别诊断。
